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Fusion gene ID: 11329 |
FusionGeneSummary for EIF4G1_MCC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4G1_MCC | Fusion gene ID: 11329 | Hgene | Tgene | Gene symbol | EIF4G1 | MCC | Gene ID | 1981 | 4163 |
| Gene name | eukaryotic translation initiation factor 4 gamma 1 | MCC, WNT signaling pathway regulator | |
| Synonyms | EIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18 | MCC1 | |
| Cytomap | 3q27.1 | 5q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 4 gamma 1EIF4-gammaeIF-4-gamma 1eucaryotic translation initiation factor 4G | colorectal mutant cancer proteinmutated in colorectal cancers | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q04637 | P23508 | |
| Ensembl transtripts involved in fusion gene | ENST00000346169, ENST00000414031, ENST00000392537, ENST00000382330, ENST00000350481, ENST00000352767, ENST00000427845, ENST00000342981, ENST00000319274, ENST00000424196, ENST00000411531, ENST00000441154, ENST00000434061, ENST00000435046, | ENST00000302475, ENST00000514701, ENST00000515367, ENST00000408903, | |
| Fusion gene scores | * DoF score | 9 X 11 X 6=594 | 7 X 8 X 5=280 |
| # samples | 14 | 8 | |
| ** MAII score | log2(14/594*10)=-2.0850361038558 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF4G1 [Title/Abstract] AND MCC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF4G1 | GO:1905612 | positive regulation of mRNA cap binding | 23409027 |
| Hgene | EIF4G1 | GO:1905618 | positive regulation of miRNA mediated inhibition of translation | 23409027 |
| Tgene | MCC | GO:0045184 | establishment of protein localization | 18591935 |
| Tgene | MCC | GO:0050680 | negative regulation of epithelial cell proliferation | 18591935 |
| Tgene | MCC | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 18591935 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ009628 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000346169 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000346169 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000346169 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000346169 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000414031 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000414031 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000414031 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000414031 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000392537 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000392537 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000392537 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000392537 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-3CDS | ENST00000382330 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000382330 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000382330 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000382330 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000350481 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000350481 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000350481 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000350481 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-3CDS | ENST00000352767 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000352767 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000352767 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000352767 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-3CDS | ENST00000427845 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000427845 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000427845 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000427845 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000342981 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000342981 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000342981 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000342981 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000319274 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000319274 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000319274 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000319274 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000424196 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000424196 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000424196 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000424196 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-3CDS | ENST00000411531 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000411531 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000411531 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000411531 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-3CDS | ENST00000441154 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000441154 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000441154 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| intron-5UTR | ENST00000441154 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000434061 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000434061 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000434061 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000434061 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-3CDS | ENST00000435046 | ENST00000302475 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000435046 | ENST00000514701 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000435046 | ENST00000515367 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
| 3UTR-5UTR | ENST00000435046 | ENST00000408903 | EIF4G1 | chr3 | 184052945 | - | MCC | chr5 | 112389659 | - |
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FusionProtFeatures for EIF4G1_MCC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4G1 | MCC |