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Fusion gene ID: 11297 |
FusionGeneSummary for EIF3M_SYNCRIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3M_SYNCRIP | Fusion gene ID: 11297 | Hgene | Tgene | Gene symbol | EIF3M | SYNCRIP | Gene ID | 10480 | 10492 |
| Gene name | eukaryotic translation initiation factor 3 subunit M | synaptotagmin binding cytoplasmic RNA interacting protein | |
| Synonyms | B5|GA17|PCID1|TANGO7|hfl-B5 | GRY-RBP|GRYRBP|HNRNPQ|HNRPQ1|NSAP1|PP68|hnRNP-Q | |
| Cytomap | 11p13 | 6q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | heterogeneous nuclear ribonucleoprotein QNS1-associated protein 1glycine- and tyrosine-rich RNA-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q7L2H7 | O60506 | |
| Ensembl transtripts involved in fusion gene | ENST00000531120, ENST00000524896, ENST00000532054, | ENST00000355238, ENST00000369622, | |
| Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 6 X 6 X 3=108 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF3M [Title/Abstract] AND SYNCRIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SYNCRIP | GO:0017148 | negative regulation of translation | 23071094 |
| Tgene | SYNCRIP | GO:0071346 | cellular response to interferon-gamma | 15479637 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC019360 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000531120 | ENST00000355238 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| 5UTR-5UTR | ENST00000531120 | ENST00000369622 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| 5UTR-5UTR | ENST00000524896 | ENST00000355238 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| 5UTR-5UTR | ENST00000524896 | ENST00000369622 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| intron-5UTR | ENST00000532054 | ENST00000355238 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
| intron-5UTR | ENST00000532054 | ENST00000369622 | EIF3M | chr11 | 32605399 | - | SYNCRIP | chr6 | 86352608 | - |
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FusionProtFeatures for EIF3M_SYNCRIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3M | SYNCRIP |