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Fusion gene ID: 11295 |
FusionGeneSummary for EIF3M_KRT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3M_KRT7 | Fusion gene ID: 11295 | Hgene | Tgene | Gene symbol | EIF3M | KRT7 | Gene ID | 10480 | 3855 |
| Gene name | eukaryotic translation initiation factor 3 subunit M | keratin 7 | |
| Synonyms | B5|GA17|PCID1|TANGO7|hfl-B5 | CK7|K2C7|K7|SCL | |
| Cytomap | 11p13 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | keratin, type II cytoskeletal 7CK-7cytokeratin 7keratin 7, type IIkeratin, 55K type II cytoskeletalkeratin, simple epithelial type I, K7sarcolectintype II mesothelial keratin K7type-II keratin Kb7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q7L2H7 | P08729 | |
| Ensembl transtripts involved in fusion gene | ENST00000531120, ENST00000524896, ENST00000532054, | ENST00000331817, ENST00000552322, | |
| Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 7 X 7 X 2=98 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF3M [Title/Abstract] AND KRT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG002942 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000531120 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| intron-intron | ENST00000531120 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| intron-intron | ENST00000524896 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| intron-intron | ENST00000524896 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| intron-intron | ENST00000532054 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
| intron-intron | ENST00000532054 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
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FusionProtFeatures for EIF3M_KRT7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3M | KRT7 |