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Fusion gene ID: 11292 |
FusionGeneSummary for EIF3L_VPS13B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3L_VPS13B | Fusion gene ID: 11292 | Hgene | Tgene | Gene symbol | EIF3L | VPS13B | Gene ID | 51386 | 157680 |
| Gene name | eukaryotic translation initiation factor 3 subunit L | vacuolar protein sorting 13 homolog B | |
| Synonyms | EIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005 | CHS1|COH1 | |
| Cytomap | 22q13.1 | 8q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting protein | vacuolar protein sorting-associated protein 13B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y262 | Q7Z7G8 | |
| Ensembl transtripts involved in fusion gene | ENST00000412331, ENST00000381683, ENST00000406934, ENST00000476955, | ENST00000395996, ENST00000358544, ENST00000357162, ENST00000355155, ENST00000441350, ENST00000521932, | |
| Fusion gene scores | * DoF score | 9 X 5 X 8=360 | 10 X 10 X 7=700 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/700*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF3L [Title/Abstract] AND VPS13B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF3L | GO:0006413 | translational initiation | 17581632 |
| Hgene | EIF3L | GO:0075525 | viral translational termination-reinitiation | 21347434 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-69-7979-01A | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000412331 | ENST00000395996 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-3UTR | ENST00000412331 | ENST00000358544 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-3UTR | ENST00000412331 | ENST00000357162 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000412331 | ENST00000355155 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000412331 | ENST00000441350 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000412331 | ENST00000521932 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-3UTR | ENST00000381683 | ENST00000395996 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-3UTR | ENST00000381683 | ENST00000358544 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-3UTR | ENST00000381683 | ENST00000357162 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000381683 | ENST00000355155 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000381683 | ENST00000441350 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| 5CDS-intron | ENST00000381683 | ENST00000521932 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000406934 | ENST00000395996 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000406934 | ENST00000358544 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000406934 | ENST00000357162 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000406934 | ENST00000355155 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000406934 | ENST00000441350 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000406934 | ENST00000521932 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000476955 | ENST00000395996 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000476955 | ENST00000358544 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-3UTR | ENST00000476955 | ENST00000357162 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000476955 | ENST00000355155 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000476955 | ENST00000441350 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
| intron-intron | ENST00000476955 | ENST00000521932 | EIF3L | chr22 | 38251651 | + | VPS13B | chr8 | 100861004 | + |
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FusionProtFeatures for EIF3L_VPS13B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3L | VPS13B |