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Fusion gene ID: 11250 |
FusionGeneSummary for EIF3B_GDI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3B_GDI2 | Fusion gene ID: 11250 | Hgene | Tgene | Gene symbol | EIF3B | GDI2 | Gene ID | 8662 | 2665 |
| Gene name | eukaryotic translation initiation factor 3 subunit B | GDP dissociation inhibitor 2 | |
| Synonyms | EIF3-ETA|EIF3-P110|EIF3-P116|EIF3S9|PRT1 | HEL-S-46e|RABGDIB | |
| Cytomap | 7p22.3 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit Beukaryotic translation initiation factor 3 subunit 9eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)eukaryotic translation initiation factor 3, subunit 9 eta, 116kDaprt1 homolog | rab GDP dissociation inhibitor betaGDI-2epididymis secretory sperm binding protein Li 46eguanosine diphosphate dissociation inhibitor 2rab GDI betarab GDP-dissociation inhibitor, beta | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P55884 | P50395 | |
| Ensembl transtripts involved in fusion gene | ENST00000360876, ENST00000397011, | ENST00000380191, ENST00000479928, ENST00000380132, ENST00000380181, | |
| Fusion gene scores | * DoF score | 8 X 11 X 4=352 | 8 X 6 X 4=192 |
| # samples | 11 | 8 | |
| ** MAII score | log2(11/352*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF3B [Title/Abstract] AND GDI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF3B | GO:0006413 | translational initiation | 8995410|17581632 |
| Hgene | EIF3B | GO:0006446 | regulation of translational initiation | 8995410 |
| Hgene | EIF3B | GO:0075522 | IRES-dependent viral translational initiation | 9573242 |
| Hgene | EIF3B | GO:0075525 | viral translational termination-reinitiation | 21347434 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-SG-A849-01A | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360876 | ENST00000380191 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000360876 | ENST00000479928 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000360876 | ENST00000380132 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000360876 | ENST00000380181 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| In-frame | ENST00000397011 | ENST00000380191 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000397011 | ENST00000479928 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000397011 | ENST00000380132 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
| 5CDS-intron | ENST00000397011 | ENST00000380181 | EIF3B | chr7 | 2418877 | + | GDI2 | chr10 | 5828013 | - |
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FusionProtFeatures for EIF3B_GDI2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3B | GDI2 |