|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 11249 |
FusionGeneSummary for EIF3B_FAM107B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3B_FAM107B | Fusion gene ID: 11249 | Hgene | Tgene | Gene symbol | EIF3B | FAM107B | Gene ID | 8662 | 83641 |
| Gene name | eukaryotic translation initiation factor 3 subunit B | family with sequence similarity 107 member B | |
| Synonyms | EIF3-ETA|EIF3-P110|EIF3-P116|EIF3S9|PRT1 | C10orf45|HITS | |
| Cytomap | 7p22.3 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit Beukaryotic translation initiation factor 3 subunit 9eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)eukaryotic translation initiation factor 3, subunit 9 eta, 116kDaprt1 homolog | protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P55884 | Q9H098 | |
| Ensembl transtripts involved in fusion gene | ENST00000360876, ENST00000397011, | ENST00000181796, ENST00000378470, ENST00000468747, ENST00000378467, ENST00000378465, ENST00000378458, ENST00000478076, ENST00000378462, ENST00000496330, ENST00000479731, ENST00000471815, | |
| Fusion gene scores | * DoF score | 8 X 11 X 4=352 | 9 X 7 X 6=378 |
| # samples | 11 | 9 | |
| ** MAII score | log2(11/352*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF3B [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF3B | GO:0006413 | translational initiation | 8995410|17581632 |
| Hgene | EIF3B | GO:0006446 | regulation of translational initiation | 8995410 |
| Hgene | EIF3B | GO:0075522 | IRES-dependent viral translational initiation | 9573242 |
| Hgene | EIF3B | GO:0075525 | viral translational termination-reinitiation | 21347434 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF812060 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000360876 | ENST00000181796 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000378470 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000468747 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000378467 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000378465 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000378458 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000478076 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000378462 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000496330 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000479731 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000360876 | ENST00000471815 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000181796 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000378470 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000468747 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000378467 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000378465 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000378458 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000478076 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000378462 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000496330 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000479731 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
| intron-intron | ENST00000397011 | ENST00000471815 | EIF3B | chr7 | 2408331 | + | FAM107B | chr10 | 14633732 | - |
Top |
FusionProtFeatures for EIF3B_FAM107B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3B | FAM107B |