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Fusion gene ID: 11228 |
FusionGeneSummary for EIF2S1_STX12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF2S1_STX12 | Fusion gene ID: 11228 | Hgene | Tgene | Gene symbol | EIF2S1 | STX12 | Gene ID | 1965 | 23673 |
| Gene name | eukaryotic translation initiation factor 2 subunit alpha | syntaxin 12 | |
| Synonyms | EIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A | STX13|STX14 | |
| Cytomap | 14q23.3 | 1p35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 2 subunit 1eIF-2-alphaeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | syntaxin-12 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P05198 | Q86Y82 | |
| Ensembl transtripts involved in fusion gene | ENST00000256383, ENST00000466499, | ENST00000373943, ENST00000468761, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 3 X 3 X 1=9 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EIF2S1 [Title/Abstract] AND STX12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STX12 | GO:0033344 | cholesterol efflux | 15469992 |
| Tgene | STX12 | GO:0050821 | protein stabilization | 15469992 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI114762 | EIF2S1 | chr14 | 67831509 | + | STX12 | chr1 | 28149343 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000256383 | ENST00000373943 | EIF2S1 | chr14 | 67831509 | + | STX12 | chr1 | 28149343 | + |
| 5CDS-intron | ENST00000256383 | ENST00000468761 | EIF2S1 | chr14 | 67831509 | + | STX12 | chr1 | 28149343 | + |
| 5CDS-3UTR | ENST00000466499 | ENST00000373943 | EIF2S1 | chr14 | 67831509 | + | STX12 | chr1 | 28149343 | + |
| 5CDS-intron | ENST00000466499 | ENST00000468761 | EIF2S1 | chr14 | 67831509 | + | STX12 | chr1 | 28149343 | + |
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FusionProtFeatures for EIF2S1_STX12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF2S1 | STX12 |