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Fusion gene ID: 11224 |
FusionGeneSummary for EIF2B5_EIF2B5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF2B5_EIF2B5 | Fusion gene ID: 11224 | Hgene | Tgene | Gene symbol | EIF2B5 | EIF2B5 | Gene ID | 8893 | 8893 |
| Gene name | eukaryotic translation initiation factor 2B subunit epsilon | eukaryotic translation initiation factor 2B subunit epsilon | |
| Synonyms | CACH|CLE|EIF-2B|EIF2Bepsilon|LVWM | CACH|CLE|EIF-2B|EIF2Bepsilon|LVWM | |
| Cytomap | 3q27.1 | 3q27.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | translation initiation factor eIF-2B subunit epsiloneIF-2B GDP-GTP exchange factor subunit epsiloneukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | translation initiation factor eIF-2B subunit epsiloneIF-2B GDP-GTP exchange factor subunit epsiloneukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13144 | Q13144 | |
| Ensembl transtripts involved in fusion gene | ENST00000444495, ENST00000273783, ENST00000432569, ENST00000498831, | ENST00000444495, ENST00000273783, ENST00000432569, ENST00000498831, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: EIF2B5 [Title/Abstract] AND EIF2B5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF2B5 | GO:0006413 | translational initiation | 16289705 |
| Hgene | EIF2B5 | GO:0050852 | T cell receptor signaling pathway | 8626696 |
| Tgene | EIF2B5 | GO:0006413 | translational initiation | 16289705 |
| Tgene | EIF2B5 | GO:0050852 | T cell receptor signaling pathway | 8626696 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM011896 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000444495 | ENST00000444495 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| Frame-shift | ENST00000444495 | ENST00000273783 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| 5CDS-intron | ENST00000444495 | ENST00000432569 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| 5CDS-intron | ENST00000444495 | ENST00000498831 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| Frame-shift | ENST00000273783 | ENST00000444495 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| Frame-shift | ENST00000273783 | ENST00000273783 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| 5CDS-intron | ENST00000273783 | ENST00000432569 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| 5CDS-intron | ENST00000273783 | ENST00000498831 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-3CDS | ENST00000432569 | ENST00000444495 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-3CDS | ENST00000432569 | ENST00000273783 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-intron | ENST00000432569 | ENST00000432569 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-intron | ENST00000432569 | ENST00000498831 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-3CDS | ENST00000498831 | ENST00000444495 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-3CDS | ENST00000498831 | ENST00000273783 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-intron | ENST00000498831 | ENST00000432569 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
| intron-intron | ENST00000498831 | ENST00000498831 | EIF2B5 | chr3 | 183860093 | - | EIF2B5 | chr3 | 183858403 | + |
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FusionProtFeatures for EIF2B5_EIF2B5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF2B5 | EIF2B5 |