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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 11208

FusionGeneSummary for EIF2AK4_EIF2AK4

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF2AK4_EIF2AK4
Fusion gene ID: 11208
HgeneTgene
Gene symbol

EIF2AK4

EIF2AK4

Gene ID

440275

440275

Gene nameeukaryotic translation initiation factor 2 alpha kinase 4eukaryotic translation initiation factor 2 alpha kinase 4
SynonymsGCN2|PVOD2GCN2|PVOD2
Cytomap

15q15.1

15q15.1

Type of geneprotein-codingprotein-coding
DescriptioneIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2
Modification date2018052320180523
UniProtAcc

Q9P2K8

Q9P2K8

Ensembl transtripts involved in fusion geneENST00000559624, ENST00000382727, 
ENST00000263791, ENST00000560648, 
ENST00000559311, 		ENST00000559624, 
ENST00000382727, ENST00000263791, 
ENST00000560648, ENST00000559311, 
Fusion gene scores* DoF score10 X 10 X 9=9004 X 6 X 4=96
# samples 117
** MAII scorelog2(11/900*10)=-3.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF2AK4 [Title/Abstract] AND EIF2AK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA230218EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
ChiTaRS3.1AB037759EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000559624ENST00000559624EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
3UTR-intronENST00000559624ENST00000382727EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
3UTR-intronENST00000559624ENST00000263791EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
3UTR-intronENST00000559624ENST00000560648EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
3UTR-intronENST00000559624ENST00000559311EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-3UTRENST00000382727ENST00000559624EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000382727ENST00000382727EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000382727ENST00000263791EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000382727ENST00000560648EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000382727ENST00000559311EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-3UTRENST00000263791ENST00000559624EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000263791ENST00000382727EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000263791ENST00000263791EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000263791ENST00000560648EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000263791ENST00000559311EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-3UTRENST00000560648ENST00000559624EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000560648ENST00000382727EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000560648ENST00000263791EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000560648ENST00000560648EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000560648ENST00000559311EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-3UTRENST00000559311ENST00000559624EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000559311ENST00000382727EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000559311ENST00000263791EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000559311ENST00000560648EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
intron-intronENST00000559311ENST00000559311EIF2AK4chr15

40266278

+EIF2AK4chr15

40266241

-
In-frameENST00000559624ENST00000559624EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000559624ENST00000382727EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000559624ENST00000263791EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000559624ENST00000560648EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000559624ENST00000559311EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000382727ENST00000559624EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000382727ENST00000382727EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000382727ENST00000263791EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000382727ENST00000560648EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000382727ENST00000559311EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000263791ENST00000559624EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000263791ENST00000382727EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
In-frameENST00000263791ENST00000263791EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000263791ENST00000560648EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
5CDS-intronENST00000263791ENST00000559311EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000560648ENST00000559624EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000560648ENST00000382727EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000560648ENST00000263791EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-intronENST00000560648ENST00000560648EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-intronENST00000560648ENST00000559311EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000559311ENST00000559624EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000559311ENST00000382727EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-3CDSENST00000559311ENST00000263791EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-intronENST00000559311ENST00000560648EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+
intron-intronENST00000559311ENST00000559311EIF2AK4chr15

40241401

-EIF2AK4chr15

40246119

+

Top

FusionProtFeatures for EIF2AK4_EIF2AK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF2AK4

Q9P2K8

EIF2AK4

Q9P2K8