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Fusion gene ID: 11185 |
FusionGeneSummary for EID2_TDRD12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EID2_TDRD12 | Fusion gene ID: 11185 | Hgene | Tgene | Gene symbol | EID2 | TDRD12 | Gene ID | 163126 | 91646 |
| Gene name | EP300 interacting inhibitor of differentiation 2 | tudor domain containing 12 | |
| Synonyms | CRI2|EID-2 | ECAT8 | |
| Cytomap | 19q13.2 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | EP300-interacting inhibitor of differentiation 2CREBBP/EP300 inhibitor 2CREBBP/EP300 inhibitory protein 2E1A like inhibitor of differentiation 2EID-1-like inhibitor of differentiation 2 | putative ATP-dependent RNA helicase TDRD12ES cell associated transcript 8ES cell-associated transcript 8 proteintudor domain-containing protein 12 | |
| Modification date | 20180519 | 20180409 | |
| UniProtAcc | Q8N6I1 | Q587J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000390658, | ENST00000444215, ENST00000421545, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 6 X 6=324 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EID2 [Title/Abstract] AND TDRD12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EID2 | GO:0007181 | transforming growth factor beta receptor complex assembly | 14612439 |
| Hgene | EID2 | GO:0007183 | SMAD protein complex assembly | 14612439 |
| Hgene | EID2 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 14612439 |
| Hgene | EID2 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 14612439 |
| Hgene | EID2 | GO:0042127 | regulation of cell proliferation | 14612439 |
| Hgene | EID2 | GO:0045892 | negative regulation of transcription, DNA-templated | 14612439 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-NA-A4QX-01A | EID2 | chr19 | 40030642 | - | TDRD12 | chr19 | 33222631 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000390658 | ENST00000444215 | EID2 | chr19 | 40030642 | - | TDRD12 | chr19 | 33222631 | + |
| intron-3CDS | ENST00000390658 | ENST00000421545 | EID2 | chr19 | 40030642 | - | TDRD12 | chr19 | 33222631 | + |
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FusionProtFeatures for EID2_TDRD12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EID2 | TDRD12 |