|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 11168 |
FusionGeneSummary for EHMT1_ATP13A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EHMT1_ATP13A1 | Fusion gene ID: 11168 | Hgene | Tgene | Gene symbol | EHMT1 | ATP13A1 | Gene ID | 79813 | 57130 |
| Gene name | euchromatic histone lysine methyltransferase 1 | ATPase 13A1 | |
| Synonyms | EHMT1-IT1|EUHMTASE1|Eu-HMTase1|FP13812|GLP|GLP1|KLEFS1|KMT1D | ATP13A|CGI-152 | |
| Cytomap | 9q34.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-m | manganese-transporting ATPase 13A1ATPase type 13A1cation transporting ATPaseprobable cation-transporting ATPase 13A1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9H9B1 | Q9HD20 | |
| Ensembl transtripts involved in fusion gene | ENST00000462484, ENST00000334856, ENST00000460843, ENST00000371394, | ENST00000291503, ENST00000357324, ENST00000496082, | |
| Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 5 X 5 X 3=75 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EHMT1 [Title/Abstract] AND ATP13A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EHMT1 | GO:0006325 | chromatin organization | 12004135 |
| Hgene | EHMT1 | GO:0016571 | histone methylation | 12004135 |
| Hgene | EHMT1 | GO:0018027 | peptidyl-lysine dimethylation | 20118233 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1733-01A | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000462484 | ENST00000291503 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| In-frame | ENST00000462484 | ENST00000357324 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 5CDS-intron | ENST00000462484 | ENST00000496082 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| In-frame | ENST00000334856 | ENST00000291503 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| In-frame | ENST00000334856 | ENST00000357324 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 5CDS-intron | ENST00000334856 | ENST00000496082 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| In-frame | ENST00000460843 | ENST00000291503 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| In-frame | ENST00000460843 | ENST00000357324 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 5CDS-intron | ENST00000460843 | ENST00000496082 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 3UTR-3CDS | ENST00000371394 | ENST00000291503 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 3UTR-3CDS | ENST00000371394 | ENST00000357324 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
| 3UTR-intron | ENST00000371394 | ENST00000496082 | EHMT1 | chr9 | 140611634 | + | ATP13A1 | chr19 | 19770796 | - |
Top |
FusionProtFeatures for EHMT1_ATP13A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EHMT1 | ATP13A1 |