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Fusion gene ID: 11092 |
FusionGeneSummary for EFTUD2_IGHJ4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EFTUD2_IGHJ4 | Fusion gene ID: 11092 | Hgene | Tgene | Gene symbol | EFTUD2 | IGHJ4 | Gene ID | 9343 | 28477 |
| Gene name | elongation factor Tu GTP binding domain containing 2 | immunoglobulin heavy joining 4 | |
| Synonyms | MFDGA|MFDM|SNRNP116|Snrp116|Snu114|U5-116KD | JH4b | |
| Cytomap | 17q21.31 | 14q32.33 | |
| Type of gene | protein-coding | other | |
| Description | 116 kDa U5 small nuclear ribonucleoprotein componentSNU114 homologU5 snRNP-specific protein, 116 kDaelongation factor Tu GTP-binding domain-containing protein 2hSNU114 | - | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q15029 | ||
| Ensembl transtripts involved in fusion gene | ENST00000426333, ENST00000592576, ENST00000591382, ENST00000402521, ENST00000589211, | ENST00000461719, | |
| Fusion gene scores | * DoF score | 10 X 10 X 7=700 | 12 X 7 X 6=504 |
| # samples | 11 | 12 | |
| ** MAII score | log2(11/700*10)=-2.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EFTUD2 [Title/Abstract] AND IGHJ4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-6145-01A | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000426333 | ENST00000461719 | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
| intron-3CDS | ENST00000592576 | ENST00000461719 | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
| intron-3CDS | ENST00000591382 | ENST00000461719 | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
| intron-3CDS | ENST00000402521 | ENST00000461719 | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
| intron-3CDS | ENST00000589211 | ENST00000461719 | EFTUD2 | chr17 | 42931061 | - | IGHJ4 | chr14 | 106330466 | - |
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FusionProtFeatures for EFTUD2_IGHJ4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EFTUD2 | IGHJ4 |