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Fusion gene ID: 11062

FusionGeneSummary for EFNA1_FLAD1

Fusion gene summary

Fusion gene information	Fusion gene name: EFNA1_FLAD1
	Fusion gene ID: 11062
		Hgene	Tgene
	Gene symbol	EFNA1	FLAD1
	Gene ID	1942	80308
	Gene name	ephrin A1	flavin adenine dinucleotide synthetase 1
	Synonyms	B61\|ECKLG\|EFL1\|EPLG1\|LERK-1\|LERK1\|TNFAIP4	FAD1\|FADS\|LSMFLAD\|PP591
	Cytomap	1q22	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	ephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1immediate early response protein B61ligand of eph-related kinase 1tumor necrosis factor, alpha-induced protein 4	FAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homolog
	Modification date	20180523	20180523
	UniProtAcc	P20827	Q8NFF5
	Ensembl transtripts involved in fusion gene	ENST00000368407, ENST00000368406, ENST00000469878,	ENST00000368433, ENST00000315144, ENST00000368432, ENST00000368431, ENST00000292180, ENST00000487371, ENST00000405236, ENST00000295530, ENST00000368428,
Fusion gene scores	* DoF score	4 X 4 X 4=64	5 X 3 X 5=75
	# samples	4	5
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EFNA1 [Title/Abstract] AND FLAD1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EFNA1	GO:0016477	cell migration	10655584
Hgene	EFNA1	GO:0033628	regulation of cell adhesion mediated by integrin	10655584
Hgene	EFNA1	GO:0034446	substrate adhesion-dependent cell spreading	10655584
Hgene	EFNA1	GO:0048013	ephrin receptor signaling pathway	10655584
Hgene	EFNA1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10655584
Hgene	EFNA1	GO:1902004	positive regulation of amyloid-beta formation	24217950

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	HNSC	TCGA-CR-7404-01A	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000368407	ENST00000368433	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
Frame-shift	ENST00000368407	ENST00000315144	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
Frame-shift	ENST00000368407	ENST00000368432	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368407	ENST00000368431	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368407	ENST00000292180	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368407	ENST00000487371	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368407	ENST00000405236	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368407	ENST00000295530	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-5UTR	ENST00000368407	ENST00000368428	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
Frame-shift	ENST00000368406	ENST00000368433	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
Frame-shift	ENST00000368406	ENST00000315144	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
Frame-shift	ENST00000368406	ENST00000368432	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368406	ENST00000368431	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368406	ENST00000292180	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368406	ENST00000487371	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368406	ENST00000405236	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-intron	ENST00000368406	ENST00000295530	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
5CDS-5UTR	ENST00000368406	ENST00000368428	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-3CDS	ENST00000469878	ENST00000368433	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-3CDS	ENST00000469878	ENST00000315144	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-3CDS	ENST00000469878	ENST00000368432	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-intron	ENST00000469878	ENST00000368431	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-intron	ENST00000469878	ENST00000292180	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-intron	ENST00000469878	ENST00000487371	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-intron	ENST00000469878	ENST00000405236	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-intron	ENST00000469878	ENST00000295530	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+
3UTR-5UTR	ENST00000469878	ENST00000368428	EFNA1	chr1	155100545	+	FLAD1	chr1	154962036	+

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FusionProtFeatures for EFNA1_FLAD1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EFNA1 P20827	FLAD1 Q8NFF5

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Fusion gene ID: 11062

FusionGeneSummary for EFNA1_FLAD1

FusionProtFeatures for EFNA1_FLAD1