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Fusion gene ID: 11005 |
FusionGeneSummary for EEF2_PABPC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EEF2_PABPC1 | Fusion gene ID: 11005 | Hgene | Tgene | Gene symbol | EEF2 | PABPC1 | Gene ID | 1938 | 26986 |
| Gene name | eukaryotic translation elongation factor 2 | poly(A) binding protein cytoplasmic 1 | |
| Synonyms | EEF-2|EF-2|EF2|SCA26 | PAB1|PABP|PABP1|PABPC2|PABPL1 | |
| Cytomap | 19p13.3 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | elongation factor 2polypeptidyl-tRNA translocase | polyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P13639 | P11940 | |
| Ensembl transtripts involved in fusion gene | ENST00000309311, ENST00000600720, | ENST00000318607, ENST00000519004, ENST00000522387, ENST00000519596, | |
| Fusion gene scores | * DoF score | 30 X 23 X 17=11730 | 7 X 8 X 3=168 |
| # samples | 50 | 8 | |
| ** MAII score | log2(50/11730*10)=-4.55213110825378 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EEF2 [Title/Abstract] AND PABPC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PABPC1 | GO:2000623 | negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 18447585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UVM | TCGA-V4-A9E7-01A | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000309311 | ENST00000318607 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-5UTR | ENST00000309311 | ENST00000519004 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-5UTR | ENST00000309311 | ENST00000522387 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-intron | ENST00000309311 | ENST00000519596 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-5UTR | ENST00000600720 | ENST00000318607 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-5UTR | ENST00000600720 | ENST00000519004 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-5UTR | ENST00000600720 | ENST00000522387 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
| intron-intron | ENST00000600720 | ENST00000519596 | EEF2 | chr19 | 3972316 | - | PABPC1 | chr8 | 101734220 | - |
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FusionProtFeatures for EEF2_PABPC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EEF2 | PABPC1 |