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Fusion gene ID: 10953 |
FusionGeneSummary for EED_TPCN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EED_TPCN2 | Fusion gene ID: 10953 | Hgene | Tgene | Gene symbol | EED | TPCN2 | Gene ID | 8726 | 219931 |
| Gene name | embryonic ectoderm development | two pore segment channel 2 | |
| Synonyms | COGIS|HEED|WAIT1 | SHEP10|TPC2 | |
| Cytomap | 11q14.2 | 11q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development protein | two pore calcium channel protein 2voltage-dependent calcium channel protein TPC2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75530 | Q8NHX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000263360, ENST00000528180, ENST00000327320, ENST00000351625, ENST00000527888, | ENST00000294309, ENST00000542467, ENST00000442692, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 10 X 7 X 6=420 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/420*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EED [Title/Abstract] AND TPCN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TPCN2 | GO:0006874 | cellular calcium ion homeostasis | 19387438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HI-7171-01A | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263360 | ENST00000294309 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000263360 | ENST00000542467 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| 5CDS-3UTR | ENST00000263360 | ENST00000442692 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000528180 | ENST00000294309 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000528180 | ENST00000542467 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| 5CDS-3UTR | ENST00000528180 | ENST00000442692 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000327320 | ENST00000294309 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000327320 | ENST00000542467 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| 5CDS-3UTR | ENST00000327320 | ENST00000442692 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000351625 | ENST00000294309 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| In-frame | ENST00000351625 | ENST00000542467 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| 5CDS-3UTR | ENST00000351625 | ENST00000442692 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| intron-3CDS | ENST00000527888 | ENST00000294309 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| intron-3CDS | ENST00000527888 | ENST00000542467 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
| intron-3UTR | ENST00000527888 | ENST00000442692 | EED | chr11 | 85956385 | + | TPCN2 | chr11 | 68834971 | + |
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FusionProtFeatures for EED_TPCN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EED | TPCN2 |