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Fusion gene ID: 10821 |
FusionGeneSummary for DYRK2_KCNC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DYRK2_KCNC2 | Fusion gene ID: 10821 | Hgene | Tgene | Gene symbol | DYRK2 | KCNC2 | Gene ID | 8445 | 3747 |
| Gene name | dual specificity tyrosine phosphorylation regulated kinase 2 | potassium voltage-gated channel subfamily C member 2 | |
| Synonyms | - | KV3.2 | |
| Cytomap | 12q15 | 12q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity tyrosine-phosphorylation-regulated kinase 2dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | potassium voltage-gated channel subfamily C member 2potassium channel, voltage gated Shaw related subfamily C, member 2potassium voltage-gated channel, Shaw-related subfamily, member 2shaw-like potassium channelvoltage-gated potassium channel Kv3.2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q92630 | Q96PR1 | |
| Ensembl transtripts involved in fusion gene | ENST00000344096, ENST00000393555, ENST00000537632, | ENST00000550433, ENST00000548513, ENST00000549446, ENST00000298972, ENST00000341669, ENST00000350228, ENST00000540018, ENST00000393288, ENST00000548243, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 13 X 4 X 5=260 |
| # samples | 6 | 12 | |
| ** MAII score | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/260*10)=-1.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DYRK2 [Title/Abstract] AND KCNC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DYRK2 | GO:0006468 | protein phosphorylation | 11311121 |
| Hgene | DYRK2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 17349958 |
| Hgene | DYRK2 | GO:0045725 | positive regulation of glycogen biosynthetic process | 11311121 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A6BF-01A | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000344096 | ENST00000550433 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000548513 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000549446 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000298972 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000341669 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000350228 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000540018 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000344096 | ENST00000393288 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-intron | ENST00000344096 | ENST00000548243 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000550433 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000548513 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000549446 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000298972 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000341669 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000350228 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000540018 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-3CDS | ENST00000393555 | ENST00000393288 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| 3UTR-intron | ENST00000393555 | ENST00000548243 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000550433 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000548513 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000549446 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000298972 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000341669 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000350228 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000540018 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-3CDS | ENST00000537632 | ENST00000393288 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
| intron-intron | ENST00000537632 | ENST00000548243 | DYRK2 | chr12 | 68052631 | + | KCNC2 | chr12 | 75445097 | - |
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FusionProtFeatures for DYRK2_KCNC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DYRK2 | KCNC2 |