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Fusion gene ID: 10790 |
FusionGeneSummary for DYNLL1_COQ5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DYNLL1_COQ5 | Fusion gene ID: 10790 | Hgene | Tgene | Gene symbol | DYNLL1 | COQ5 | Gene ID | 8655 | 84274 |
| Gene name | dynein light chain LC8-type 1 | coenzyme Q5, methyltransferase | |
| Synonyms | DLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1 | - | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dynein light chain 1, cytoplasmic8 kDa dynein light chaincytoplasmic dynein light polypeptidedynein, cytoplasmic, light polypeptide 1protein inhibitor of neuronal nitric oxide synthase | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialcoenzyme Q5 homolog, methyltransferaseubiquinone biosynthesis methyltransferase COQ5, mitochondrial | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P63167 | Q5HYK3 | |
| Ensembl transtripts involved in fusion gene | ENST00000392509, ENST00000548342, ENST00000242577, ENST00000548214, ENST00000392508, ENST00000550178, ENST00000550845, ENST00000549989, ENST00000552870, ENST00000552316, | ENST00000288532, ENST00000445328, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DYNLL1 [Title/Abstract] AND COQ5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DYNLL1 | GO:0042326 | negative regulation of phosphorylation | 18579519 |
| Tgene | COQ5 | GO:0032259 | methylation | 25152161 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-F7-7848-01A | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000392509 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| 5UTR-3CDS | ENST00000392509 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| 5UTR-3CDS | ENST00000548342 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| 5UTR-3CDS | ENST00000548342 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000242577 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000242577 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000548214 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000548214 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000392508 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000392508 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000550178 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000550178 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000550845 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000550845 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000549989 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000549989 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000552870 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000552870 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000552316 | ENST00000288532 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
| intron-3CDS | ENST00000552316 | ENST00000445328 | DYNLL1 | chr12 | 120907907 | + | COQ5 | chr12 | 120947926 | - |
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FusionProtFeatures for DYNLL1_COQ5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DYNLL1 | COQ5 |