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Fusion gene ID: 10775 |
FusionGeneSummary for DYNC1LI2_NAE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DYNC1LI2_NAE1 | Fusion gene ID: 10775 | Hgene | Tgene | Gene symbol | DYNC1LI2 | NAE1 | Gene ID | 1783 | 8883 |
| Gene name | dynein cytoplasmic 1 light intermediate chain 2 | NEDD8 activating enzyme E1 subunit 1 | |
| Synonyms | DNCLI2|LIC2 | A-116A10.1|APPBP1|HPP1|ula-1 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic dynein 1 light intermediate chain 2LIC-2LIC53/55dynein light intermediate chain 2, cytosolicdynein, cytoplasmic, light intermediate polypeptide 2 | NEDD8-activating enzyme E1 regulatory subunitAPP-BP1NEDD8-activating enzyme E1 subunitamyloid beta precursor protein binding protein 1, 59kDaamyloid beta precursor protein-binding protein 1, 59 kDaamyloid beta precursor protein-binding protein 1, 59k | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43237 | Q13564 | |
| Ensembl transtripts involved in fusion gene | ENST00000258198, ENST00000379482, ENST00000443351, ENST00000570201, ENST00000440564, | ENST00000359087, ENST00000290810, ENST00000379463, ENST00000394074, ENST00000564040, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 4 X 2=24 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DYNC1LI2 [Title/Abstract] AND NAE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NAE1 | GO:0033314 | mitotic DNA replication checkpoint | 10722740 |
| Tgene | NAE1 | GO:0042981 | regulation of apoptotic process | 14557245 |
| Tgene | NAE1 | GO:0043523 | regulation of neuron apoptotic process | 10722740 |
| Tgene | NAE1 | GO:0045116 | protein neddylation | 10207026|12740388 |
| Tgene | NAE1 | GO:0051402 | neuron apoptotic process | 14557245 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-VR-A8Q7-01A | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000258198 | ENST00000359087 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000258198 | ENST00000290810 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000258198 | ENST00000379463 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000258198 | ENST00000394074 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| 5CDS-intron | ENST00000258198 | ENST00000564040 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000379482 | ENST00000359087 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000379482 | ENST00000290810 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000379482 | ENST00000379463 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000379482 | ENST00000394074 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| 5CDS-intron | ENST00000379482 | ENST00000564040 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000443351 | ENST00000359087 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000443351 | ENST00000290810 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000443351 | ENST00000379463 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| In-frame | ENST00000443351 | ENST00000394074 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| 5CDS-intron | ENST00000443351 | ENST00000564040 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000570201 | ENST00000359087 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000570201 | ENST00000290810 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000570201 | ENST00000379463 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000570201 | ENST00000394074 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-intron | ENST00000570201 | ENST00000564040 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000440564 | ENST00000359087 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000440564 | ENST00000290810 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000440564 | ENST00000379463 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-3CDS | ENST00000440564 | ENST00000394074 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
| intron-intron | ENST00000440564 | ENST00000564040 | DYNC1LI2 | chr16 | 66783100 | - | NAE1 | chr16 | 66839929 | - |
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FusionProtFeatures for DYNC1LI2_NAE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DYNC1LI2 | NAE1 |