|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10640 |
FusionGeneSummary for DTD1_SEC23B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DTD1_SEC23B | Fusion gene ID: 10640 | Hgene | Tgene | Gene symbol | DTD1 | SEC23B | Gene ID | 92675 | 10483 |
| Gene name | D-tyrosyl-tRNA deacylase 1 | Sec23 homolog B, coat complex II component | |
| Synonyms | C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68 | CDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23B | |
| Cytomap | 20p11.23 | 20p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2 | protein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TEA8 | Q15437 | |
| Ensembl transtripts involved in fusion gene | ENST00000377452, ENST00000494921, | ENST00000262544, ENST00000336714, ENST00000377475, ENST00000377465, ENST00000494645, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 4 X 5 X 3=60 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/60*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DTD1 [Title/Abstract] AND SEC23B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0727-01A | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000377452 | ENST00000262544 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000377452 | ENST00000336714 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000377452 | ENST00000377475 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000377452 | ENST00000377465 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-intron | ENST00000377452 | ENST00000494645 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000494921 | ENST00000262544 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000494921 | ENST00000336714 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000494921 | ENST00000377475 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-3CDS | ENST00000494921 | ENST00000377465 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
| intron-intron | ENST00000494921 | ENST00000494645 | DTD1 | chr20 | 18548240 | + | SEC23B | chr20 | 18541295 | + |
Top |
FusionProtFeatures for DTD1_SEC23B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DTD1 | SEC23B |