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Fusion gene ID: 10638 |
FusionGeneSummary for DTD1_POU2F3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DTD1_POU2F3 | Fusion gene ID: 10638 | Hgene | Tgene | Gene symbol | DTD1 | POU2F3 | Gene ID | 92675 | 25833 |
| Gene name | D-tyrosyl-tRNA deacylase 1 | POU class 2 homeobox 3 | |
| Synonyms | C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68 | Epoc-1|OCT-11|OCT11|OTF-11|PLA-1|PLA1|Skn-1a | |
| Cytomap | 20p11.23 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2 | POU domain, class 2, transcription factor 3POU domain transcription factor OCT11aoctamer-binding protein 11octamer-binding transcription factor 11transcription factor PLA-1transcription factor Skn-1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TEA8 | Q9UKI9 | |
| Ensembl transtripts involved in fusion gene | ENST00000377452, ENST00000494921, | ENST00000260264, ENST00000543440, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 3 X 2 X 3=18 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DTD1 [Title/Abstract] AND POU2F3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POU2F3 | GO:0043922 | negative regulation by host of viral transcription | 14645924 |
| Tgene | POU2F3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12624109 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-38-4632-01A | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377452 | ENST00000260264 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| In-frame | ENST00000377452 | ENST00000543440 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| 3UTR-3CDS | ENST00000494921 | ENST00000260264 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| 3UTR-3CDS | ENST00000494921 | ENST00000543440 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
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FusionProtFeatures for DTD1_POU2F3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DTD1 | POU2F3 |