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Fusion gene ID: 10630

FusionGeneSummary for DST_MLIP

Fusion gene summary

Fusion gene information	Fusion gene name: DST_MLIP
	Fusion gene ID: 10630
		Hgene	Tgene
	Gene symbol	DST	MLIP
	Gene ID	667	90523
	Gene name	dystonin	muscular LMNA interacting protein
	Synonyms	BP240\|BPA\|BPAG1\|CATX-15\|CATX15\|D6S1101\|DMH\|DT\|EBSB2\|HSAN6\|MACF2	C6orf142\|CIP
	Cytomap	6p12.1	6p12.1
	Type of gene	protein-coding	protein-coding
	Description	dystoninbullous pemphigoid antigen 1dystonia musculorum proteinhemidesmosomal plaque proteintrabeculin-beta	muscular LMNA-interacting proteincardiac ISL1-interacting proteinmuscle-enriched A-type lamin interacting proteinmuscular-enriched A-type laminin-interacting protein
	Modification date	20180523	20180519
	UniProtAcc	Q03001	Q5VWP3
	Ensembl transtripts involved in fusion gene	ENST00000421834, ENST00000370769, ENST00000312431, ENST00000370754, ENST00000370788, ENST00000361203, ENST00000244364, ENST00000446842, ENST00000340834, ENST00000370765, ENST00000518935,	ENST00000514921, ENST00000274897, ENST00000370877, ENST00000509997, ENST00000370876, ENST00000511744, ENST00000358276, ENST00000502396,
Fusion gene scores	* DoF score	15 X 16 X 9=2160	6 X 5 X 7=210
	# samples	17	8
	** MAII score	log2(17/2160*10)=-3.66742466091313 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DST [Title/Abstract] AND MLIP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DST	GO:0009611	response to wounding	19403692

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SKCM	TCGA-DA-A1I0-06A	DST	chr6	56371241	-	MLIP	chr6	53986245	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000421834	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000421834	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000421834	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000421834	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000421834	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000421834	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000421834	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000421834	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370769	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370769	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370769	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370769	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370769	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370769	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370769	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370769	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-3CDS	ENST00000312431	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-3CDS	ENST00000312431	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-intron	ENST00000312431	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-intron	ENST00000312431	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-intron	ENST00000312431	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-3UTR	ENST00000312431	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-3UTR	ENST00000312431	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
3UTR-3UTR	ENST00000312431	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370754	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370754	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370754	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370754	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370754	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370754	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370754	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370754	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370788	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000370788	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370788	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370788	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000370788	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370788	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370788	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000370788	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000361203	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000361203	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000361203	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000361203	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000361203	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000361203	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000361203	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000361203	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000244364	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000244364	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000244364	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000244364	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000244364	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000244364	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000244364	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000244364	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000446842	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
In-frame	ENST00000446842	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000446842	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000446842	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-intron	ENST00000446842	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000446842	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000446842	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5CDS-3UTR	ENST00000446842	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-3CDS	ENST00000340834	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-3CDS	ENST00000340834	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-intron	ENST00000340834	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-intron	ENST00000340834	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-intron	ENST00000340834	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-3UTR	ENST00000340834	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-3UTR	ENST00000340834	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
5UTR-3UTR	ENST00000340834	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3CDS	ENST00000370765	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3CDS	ENST00000370765	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000370765	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000370765	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000370765	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000370765	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000370765	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000370765	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3CDS	ENST00000518935	ENST00000514921	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3CDS	ENST00000518935	ENST00000274897	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000518935	ENST00000370877	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000518935	ENST00000509997	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-intron	ENST00000518935	ENST00000370876	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000518935	ENST00000511744	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000518935	ENST00000358276	DST	chr6	56371241	-	MLIP	chr6	53986245	+
intron-3UTR	ENST00000518935	ENST00000502396	DST	chr6	56371241	-	MLIP	chr6	53986245	+

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FusionProtFeatures for DST_MLIP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DST Q03001	MLIP Q5VWP3

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Fusion gene ID: 10630

FusionGeneSummary for DST_MLIP

FusionProtFeatures for DST_MLIP