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Fusion gene ID: 10618

FusionGeneSummary for DSTYK_NAV1

Fusion gene summary

Fusion gene information	Fusion gene name: DSTYK_NAV1
	Fusion gene ID: 10618
		Hgene	Tgene
	Gene symbol	DSTYK	NAV1
	Gene ID	25778	89796
	Gene name	dual serine/threonine and tyrosine protein kinase	neuron navigator 1
	Synonyms	CAKUT1\|DustyPK\|HDCMD38P\|RIP5\|RIPK5\|SPG23	POMFIL3\|STEERIN1\|UNC53H1
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	dual serine/threonine and tyrosine protein kinaseRIP-homologous kinasedusty PKdusty protein kinasereceptor-interacting serine/threonine-protein kinase 5sgK496sugen kinase 496	neuron navigator 1pore membrane and/or filament interacting like protein 3unc-53 homolog 1
	Modification date	20180522	20180523
	UniProtAcc	Q6XUX3	Q8NEY1
	Ensembl transtripts involved in fusion gene	ENST00000367160, ENST00000367161, ENST00000367162,	ENST00000367302, ENST00000367296, ENST00000295624, ENST00000367297, ENST00000367300, ENST00000367295, ENST00000469130,
Fusion gene scores	* DoF score	7 X 2 X 8=112	7 X 6 X 3=126
	# samples	8	9
	** MAII score	log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/126*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DSTYK [Title/Abstract] AND NAV1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DSTYK	GO:0044344	cellular response to fibroblast growth factor stimulus	23862974

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AR-A24Z-01A	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000367160	ENST00000367302	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367160	ENST00000367296	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367160	ENST00000295624	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367160	ENST00000367297	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367160	ENST00000367300	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367160	ENST00000367295	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
5CDS-intron	ENST00000367160	ENST00000469130	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000367302	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000367296	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000295624	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000367297	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000367300	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367161	ENST00000367295	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
5CDS-intron	ENST00000367161	ENST00000469130	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000367302	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000367296	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000295624	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000367297	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000367300	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
Frame-shift	ENST00000367162	ENST00000367295	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+
5CDS-intron	ENST00000367162	ENST00000469130	DSTYK	chr1	205180399	-	NAV1	chr1	201749549	+

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FusionProtFeatures for DSTYK_NAV1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSTYK Q6XUX3	NAV1 Q8NEY1

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Fusion gene ID: 10618

FusionGeneSummary for DSTYK_NAV1

FusionProtFeatures for DSTYK_NAV1