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Fusion gene ID: 10609 |
FusionGeneSummary for DSTN_DZANK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSTN_DZANK1 | Fusion gene ID: 10609 | Hgene | Tgene | Gene symbol | DSTN | DZANK1 | Gene ID | 11034 | 55184 |
| Gene name | destrin, actin depolymerizing factor | double zinc ribbon and ankyrin repeat domains 1 | |
| Synonyms | ACTDP|ADF|HEL32|bA462D18.2 | ANKRD64|C20orf12|C20orf84|bA189K21.1|bA189K21.8|dJ568F9.2 | |
| Cytomap | 20p12.1 | 20p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | destrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32 | double zinc ribbon and ankyrin repeat-containing protein 1ankyrin repeat domain 64ankyrin repeat-containing protein C20orf12 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P60981 | Q9NVP4 | |
| Ensembl transtripts involved in fusion gene | ENST00000246069, ENST00000474024, | ENST00000357236, ENST00000329494, ENST00000262547, ENST00000487128, ENST00000358866, | |
| Fusion gene scores | * DoF score | 10 X 4 X 7=280 | 3 X 3 X 3=27 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DSTN [Title/Abstract] AND DZANK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DSTN | GO:0030042 | actin filament depolymerization | 11812157 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-8206-01A | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000246069 | ENST00000357236 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5CDS-5UTR | ENST00000246069 | ENST00000329494 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5CDS-5UTR | ENST00000246069 | ENST00000262547 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5CDS-intron | ENST00000246069 | ENST00000487128 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5CDS-intron | ENST00000246069 | ENST00000358866 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000357236 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000329494 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000262547 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5UTR-intron | ENST00000474024 | ENST00000487128 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
| 5UTR-intron | ENST00000474024 | ENST00000358866 | DSTN | chr20 | 17550856 | + | DZANK1 | chr20 | 18436005 | - |
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FusionProtFeatures for DSTN_DZANK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSTN | DZANK1 |