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Fusion gene ID: 10603 |
FusionGeneSummary for DSTN_ARPC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSTN_ARPC5 | Fusion gene ID: 10603 | Hgene | Tgene | Gene symbol | DSTN | ARPC5 | Gene ID | 11034 | 10092 |
| Gene name | destrin, actin depolymerizing factor | actin related protein 2/3 complex subunit 5 | |
| Synonyms | ACTDP|ADF|HEL32|bA462D18.2 | ARC16|dJ127C7.3|p16-Arc | |
| Cytomap | 20p12.1 | 1q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | destrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32 | actin-related protein 2/3 complex subunit 5Arp2/3 protein complex subunit p16actin related protein 2/3 complex, subunit 5, 16kDaarp2/3 complex 16 kDa subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P60981 | O15511 | |
| Ensembl transtripts involved in fusion gene | ENST00000246069, ENST00000474024, | ENST00000367534, ENST00000462965, ENST00000359856, ENST00000294742, | |
| Fusion gene scores | * DoF score | 10 X 4 X 7=280 | 3 X 3 X 2=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DSTN [Title/Abstract] AND ARPC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DSTN | GO:0030042 | actin filament depolymerization | 11812157 |
| Tgene | ARPC5 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 11741539 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-52-7812-01A | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000246069 | ENST00000367534 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5CDS-5UTR | ENST00000246069 | ENST00000462965 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5CDS-5UTR | ENST00000246069 | ENST00000359856 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5CDS-5UTR | ENST00000246069 | ENST00000294742 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5UTR-3CDS | ENST00000474024 | ENST00000367534 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000462965 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000359856 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
| 5UTR-5UTR | ENST00000474024 | ENST00000294742 | DSTN | chr20 | 17550856 | + | ARPC5 | chr1 | 183599772 | - |
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FusionProtFeatures for DSTN_ARPC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSTN | ARPC5 |