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Fusion gene ID: 10598 |
FusionGeneSummary for DSP_HDLBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSP_HDLBP | Fusion gene ID: 10598 | Hgene | Tgene | Gene symbol | DSP | HDLBP | Gene ID | 1832 | 3069 |
| Gene name | desmoplakin | high density lipoprotein binding protein | |
| Synonyms | DCWHKTA|DP | HBP|PRO2900|VGL | |
| Cytomap | 6p24.3 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | desmoplakin250/210 kDa paraneoplastic pemphigus antigen | vigilinHDL-binding protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P15924 | Q00341 | |
| Ensembl transtripts involved in fusion gene | ENST00000379802, ENST00000418664, | ENST00000391976, ENST00000310931, ENST00000391975, ENST00000427183, ENST00000476807, | |
| Fusion gene scores | * DoF score | 7 X 9 X 6=378 | 15 X 14 X 6=1260 |
| # samples | 11 | 16 | |
| ** MAII score | log2(11/378*10)=-1.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DSP [Title/Abstract] AND HDLBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DSP | GO:0018149 | peptide cross-linking | 10908733 |
| Hgene | DSP | GO:0030216 | keratinocyte differentiation | 10908733 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-DM-A0X9-01A | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000379802 | ENST00000391976 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000379802 | ENST00000310931 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000379802 | ENST00000391975 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000379802 | ENST00000427183 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| 5CDS-intron | ENST00000379802 | ENST00000476807 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000418664 | ENST00000391976 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000418664 | ENST00000310931 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000418664 | ENST00000391975 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| Frame-shift | ENST00000418664 | ENST00000427183 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
| 5CDS-intron | ENST00000418664 | ENST00000476807 | DSP | chr6 | 7575721 | + | HDLBP | chr2 | 242170359 | - |
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FusionProtFeatures for DSP_HDLBP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSP | HDLBP |