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Fusion gene ID: 10587 |
FusionGeneSummary for DSG1_TNXB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSG1_TNXB | Fusion gene ID: 10587 | Hgene | Tgene | Gene symbol | DSG1 | TNXB | Gene ID | 1828 | 7148 |
| Gene name | desmoglein 1 | tenascin XB | |
| Synonyms | CDHF4|DG1|DSG|EPKHE|EPKHIA|PPKS1|SPPK1 | EDS3|EDSCLL|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS | |
| Cytomap | 18q12.1 | 6p21.33-p21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | desmoglein-1cadherin family member 4desmosomal glycoprotein 1pemphigus foliaceus antigen | tenascin-Xgrowth-inhibiting protein 45hexabrachion-like proteintenascin XB1tenascin XB2 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q02413 | P22105 | |
| Ensembl transtripts involved in fusion gene | ENST00000257192, ENST00000462981, | ENST00000375244, ENST00000451343, ENST00000375247, ENST00000479795, ENST00000433037, ENST00000549232, ENST00000383159, ENST00000489006, ENST00000469250, ENST00000440248, ENST00000550212, ENST00000548649, ENST00000424718, ENST00000475986, ENST00000550539, ENST00000471059, ENST00000551808, ENST00000548628, ENST00000549652, ENST00000553092, ENST00000552665, ENST00000465958, ENST00000546684, ENST00000464376, ENST00000552149, ENST00000551201, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 5=180 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DSG1 [Title/Abstract] AND TNXB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DSG1 | GO:0050821 | protein stabilization | 7983064 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A922-01A | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000257192 | ENST00000375244 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000451343 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000375247 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000479795 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000433037 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000549232 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000383159 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000489006 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000469250 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000440248 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000550212 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000548649 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000424718 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000475986 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000550539 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000471059 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000551808 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000548628 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000549652 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000553092 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000552665 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000465958 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000546684 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000464376 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000552149 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| 5CDS-intron | ENST00000257192 | ENST00000551201 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-3CDS | ENST00000462981 | ENST00000375244 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000451343 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000375247 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000479795 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000433037 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000549232 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000383159 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000489006 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000469250 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000440248 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000550212 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000548649 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000424718 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000475986 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000550539 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000471059 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000551808 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000548628 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000549652 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000553092 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000552665 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000465958 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000546684 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000464376 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000552149 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
| intron-intron | ENST00000462981 | ENST00000551201 | DSG1 | chr18 | 28919988 | + | TNXB | chr6 | 32038191 | - |
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FusionProtFeatures for DSG1_TNXB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSG1 | TNXB |