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Fusion gene ID: 10581 |
FusionGeneSummary for DSE_CSNK1E |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSE_CSNK1E | Fusion gene ID: 10581 | Hgene | Tgene | Gene symbol | DSE | CSNK1E | Gene ID | 29940 | 1454 |
| Gene name | dermatan sulfate epimerase | casein kinase 1 epsilon | |
| Synonyms | DS-epi1|DSEP|DSEPI|EDSMC2|SART-2|SART2 | CKIe|CKIepsilon|HCKIE | |
| Cytomap | 6q22.1 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dermatan-sulfate epimeraseDS epimerasechondroitin-glucuronate 5-epimerasesquamous cell carcinoma antigen recognized by T-cells 2 | casein kinase I isoform epsilon | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UL01 | P49674 | |
| Ensembl transtripts involved in fusion gene | ENST00000540275, ENST00000452085, ENST00000537543, ENST00000331677, ENST00000359564, ENST00000606265, | ENST00000359867, ENST00000396832, ENST00000400206, ENST00000403904, ENST00000413574, ENST00000405675, ENST00000498529, | |
| Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 8 X 6 X 4=192 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/105*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DSE [Title/Abstract] AND CSNK1E [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DSE | GO:0030208 | dermatan sulfate biosynthetic process | 16505484 |
| Tgene | CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
| Tgene | CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Tgene | CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
| Tgene | CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
| Tgene | CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | M62263 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000540275 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000540275 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000452085 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000537543 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000331677 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000359564 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000359867 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000396832 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000400206 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000403904 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000413574 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000405675 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
| intron-intron | ENST00000606265 | ENST00000498529 | DSE | chr6 | 116596548 | - | CSNK1E | chr22 | 38689528 | - |
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FusionProtFeatures for DSE_CSNK1E |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSE | CSNK1E |