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Fusion gene ID: 10562 |
FusionGeneSummary for DROSHA_UGT3A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DROSHA_UGT3A2 | Fusion gene ID: 10562 | Hgene | Tgene | Gene symbol | DROSHA | UGT3A2 | Gene ID | 29102 | 167127 |
| Gene name | drosha ribonuclease III | UDP glycosyltransferase family 3 member A2 | |
| Synonyms | ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN | - | |
| Cytomap | 5p13.3 | 5p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclear | UDP-glucuronosyltransferase 3A2UDP glycosyltransferase 3 family, polypeptide A2UDPGT 3A2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NRR4 | Q3SY77 | |
| Ensembl transtripts involved in fusion gene | ENST00000511367, ENST00000442743, ENST00000344624, ENST00000513349, ENST00000504361, | ENST00000282507, ENST00000513300, ENST00000545528, ENST00000504954, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DROSHA [Title/Abstract] AND UGT3A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DROSHA | GO:0031053 | primary miRNA processing | 14508493|15574589 |
| Hgene | DROSHA | GO:0050829 | defense response to Gram-negative bacterium | 20180804 |
| Hgene | DROSHA | GO:0050830 | defense response to Gram-positive bacterium | 20180804 |
| Tgene | UGT3A2 | GO:0071412 | cellular response to genistein | 22621930 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-A9TE-01A | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000511367 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-intron | ENST00000511367 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000511367 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000511367 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| Frame-shift | ENST00000442743 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-intron | ENST00000442743 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000442743 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000442743 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| Frame-shift | ENST00000344624 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-intron | ENST00000344624 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000344624 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000344624 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| Frame-shift | ENST00000513349 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-intron | ENST00000513349 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000513349 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| 5CDS-5UTR | ENST00000513349 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| intron-3CDS | ENST00000504361 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| intron-intron | ENST00000504361 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| intron-5UTR | ENST00000504361 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
| intron-5UTR | ENST00000504361 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
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FusionProtFeatures for DROSHA_UGT3A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DROSHA | UGT3A2 |