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Fusion gene ID: 10552 |
FusionGeneSummary for DRAM1_SYCP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DRAM1_SYCP3 | Fusion gene ID: 10552 | Hgene | Tgene | Gene symbol | DRAM1 | SYCP3 | Gene ID | 55332 | 50511 |
| Gene name | DNA damage regulated autophagy modulator 1 | synaptonemal complex protein 3 | |
| Synonyms | DRAM | COR1|RPRGL4|SCP3|SPGF4 | |
| Cytomap | 12q23.2 | 12q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA damage-regulated autophagy modulator protein 1damage-regulated autophagy modulator | synaptonemal complex protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N682 | Q8IZU3 | |
| Ensembl transtripts involved in fusion gene | ENST00000258534, ENST00000544152, | ENST00000266743, ENST00000392927, ENST00000392924, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DRAM1 [Title/Abstract] AND SYCP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DRAM1 | GO:0010506 | regulation of autophagy | 19895784 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-JY-A6FH-01A | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000258534 | ENST00000266743 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| Frame-shift | ENST00000258534 | ENST00000392927 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| Frame-shift | ENST00000258534 | ENST00000392924 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| Frame-shift | ENST00000544152 | ENST00000266743 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| Frame-shift | ENST00000544152 | ENST00000392927 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
| Frame-shift | ENST00000544152 | ENST00000392924 | DRAM1 | chr12 | 102271698 | + | SYCP3 | chr12 | 102128822 | - |
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FusionProtFeatures for DRAM1_SYCP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DRAM1 | SYCP3 |