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Fusion gene ID: 10535 |
FusionGeneSummary for DPYSL2_NFU1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DPYSL2_NFU1 | Fusion gene ID: 10535 | Hgene | Tgene | Gene symbol | DPYSL2 | NFU1 | Gene ID | 1808 | 27247 |
| Gene name | dihydropyrimidinase like 2 | NFU1 iron-sulfur cluster scaffold | |
| Synonyms | CRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2 | CGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU | |
| Cytomap | 8p21.2 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2 | NFU1 iron-sulfur cluster scaffold homolog, mitochondrialHIRA-interacting protein 5NifU-like C-terminal domain containingiron-sulfur cluster scaffold protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q16555 | Q9UMS0 | |
| Ensembl transtripts involved in fusion gene | ENST00000521913, ENST00000311151, ENST00000523027, ENST00000521983, | ENST00000410022, ENST00000471185, ENST00000303698, ENST00000394305, ENST00000462320, | |
| Fusion gene scores | * DoF score | 9 X 7 X 3=189 | 2 X 5 X 5=50 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/189*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: DPYSL2 [Title/Abstract] AND NFU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NFU1 | GO:0016226 | iron-sulfur cluster assembly | 12886008|28906594 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP350453 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000521913 | ENST00000410022 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000521913 | ENST00000471185 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000521913 | ENST00000303698 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000521913 | ENST00000394305 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000521913 | ENST00000462320 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-3CDS | ENST00000311151 | ENST00000410022 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000311151 | ENST00000471185 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000311151 | ENST00000303698 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000311151 | ENST00000394305 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| 3UTR-5UTR | ENST00000311151 | ENST00000462320 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-3CDS | ENST00000523027 | ENST00000410022 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000523027 | ENST00000471185 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000523027 | ENST00000303698 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000523027 | ENST00000394305 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000523027 | ENST00000462320 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-3CDS | ENST00000521983 | ENST00000410022 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000521983 | ENST00000471185 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000521983 | ENST00000303698 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000521983 | ENST00000394305 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
| intron-5UTR | ENST00000521983 | ENST00000462320 | DPYSL2 | chr8 | 26514277 | + | NFU1 | chr2 | 69642390 | - |
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FusionProtFeatures for DPYSL2_NFU1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DPYSL2 | NFU1 |