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Fusion gene ID: 1047 |
FusionGeneSummary for AGAP1_ADAMTS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGAP1_ADAMTS2 | Fusion gene ID: 1047 | Hgene | Tgene | Gene symbol | AGAP1 | ADAMTS2 | Gene ID | 116987 | 9509 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | ADAM metallopeptidase with thrombospondin type 1 motif 2 | |
| Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | ADAM-TS2|ADAMTS-2|ADAMTS-3|EDSDERMS|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI | |
| Cytomap | 2q37.2 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | A disintegrin and metalloproteinase with thrombospondin motifs 2a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2procollagen I N-proteinaseprocollagen I/II amino propeptide-processing enzymeprocollagen N-endo | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UPQ3 | O95450 | |
| Ensembl transtripts involved in fusion gene | ENST00000336665, ENST00000304032, ENST00000409538, ENST00000428334, ENST00000409457, | ENST00000251582, ENST00000274609, | |
| Fusion gene scores | * DoF score | 25 X 11 X 14=3850 | 5 X 5 X 3=75 |
| # samples | 26 | 5 | |
| ** MAII score | log2(26/3850*10)=-3.88827491744117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGAP1 [Title/Abstract] AND ADAMTS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HI-7168-01A | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336665 | ENST00000251582 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| 5CDS-intron | ENST00000336665 | ENST00000274609 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| In-frame | ENST00000304032 | ENST00000251582 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| 5CDS-intron | ENST00000304032 | ENST00000274609 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| In-frame | ENST00000409538 | ENST00000251582 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| 5CDS-intron | ENST00000409538 | ENST00000274609 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| In-frame | ENST00000428334 | ENST00000251582 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| 5CDS-intron | ENST00000428334 | ENST00000274609 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| In-frame | ENST00000409457 | ENST00000251582 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
| 5CDS-intron | ENST00000409457 | ENST00000274609 | AGAP1 | chr2 | 236653483 | + | ADAMTS2 | chr5 | 178553131 | - |
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FusionProtFeatures for AGAP1_ADAMTS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGAP1 | ADAMTS2 |