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Fusion gene ID: 1044

FusionGeneSummary for AFTPH_WDPCP

Fusion gene summary

Fusion gene information	Fusion gene name: AFTPH_WDPCP
	Fusion gene ID: 1044
		Hgene	Tgene
	Gene symbol	AFTPH	WDPCP
	Gene ID	54812	51057
	Gene name	aftiphilin	WD repeat containing planar cell polarity effector
	Synonyms	Nbla10388	BBS15\|C2orf86\|CHDTHP\|CPLANE5\|FRITZ\|FRTZ
	Cytomap	2p14	2p15
	Type of gene	protein-coding	protein-coding
	Description	aftiphilinaftiphilin protein	WD repeat-containing and planar cell polarity effector protein fritz homologBardet-Biedl syndrome 15 proteinWD repeat-containing protein C2orf86ciliogenesis and planar polarity effector 5
	Modification date	20180523	20180523
	UniProtAcc	Q6ULP2	O95876
	Ensembl transtripts involved in fusion gene	ENST00000238855, ENST00000422803, ENST00000238856, ENST00000409933, ENST00000409183, ENST00000487769,	ENST00000272321, ENST00000409199, ENST00000409120, ENST00000398544, ENST00000409562, ENST00000409835,
Fusion gene scores	* DoF score	6 X 5 X 5=150	3 X 2 X 3=18
	# samples	7	4
	** MAII score	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: AFTPH [Title/Abstract] AND WDPCP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CR736341	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
ChiTaRS3.1			CR747938	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000238855	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238855	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238855	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238855	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238855	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238855	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000422803	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000238856	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409933	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000409183	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000272321	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000409199	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000409120	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000398544	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000409562	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+
intron-intron	ENST00000487769	ENST00000409835	AFTPH	chr2	64803916	+	WDPCP	chr2	63383853	+

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FusionProtFeatures for AFTPH_WDPCP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AFTPH Q6ULP2	WDPCP O95876

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Fusion gene ID: 1044

FusionGeneSummary for AFTPH_WDPCP

FusionProtFeatures for AFTPH_WDPCP