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Fusion gene ID: 10438 |
FusionGeneSummary for DOPEY1_RNF144B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOPEY1_RNF144B | Fusion gene ID: 10438 | Hgene | Tgene | Gene symbol | DOPEY1 | RNF144B | Gene ID | 23033 | 255488 |
| Gene name | dopey family member 1 | ring finger protein 144B | |
| Synonyms | DOP1|KIAA1117|dJ202D23.2 | IBRDC2|PIR2|bA528A10.3|p53RFP | |
| Cytomap | 6q14.1 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein dopey-1homolog of yeast DOP1 | E3 ubiquitin-protein ligase RNF144BIBR domain containing 2IBR domain-containing protein 2p53-inducible RING finger protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5JWR5 | Q7Z419 | |
| Ensembl transtripts involved in fusion gene | ENST00000237163, ENST00000349129, ENST00000536812, ENST00000369739, ENST00000484282, | ENST00000429054, ENST00000259939, ENST00000486622, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 4 X 3=48 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOPEY1 [Title/Abstract] AND RNF144B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RNF144B | GO:0006511 | ubiquitin-dependent protein catabolic process | 12853982 |
| Tgene | RNF144B | GO:0043066 | negative regulation of apoptotic process | 20300062 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-AA-3685-01A | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000237163 | ENST00000429054 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-5UTR | ENST00000237163 | ENST00000259939 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-3UTR | ENST00000237163 | ENST00000486622 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-intron | ENST00000349129 | ENST00000429054 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-5UTR | ENST00000349129 | ENST00000259939 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-3UTR | ENST00000349129 | ENST00000486622 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-intron | ENST00000536812 | ENST00000429054 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-5UTR | ENST00000536812 | ENST00000259939 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| 5UTR-3UTR | ENST00000536812 | ENST00000486622 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-intron | ENST00000369739 | ENST00000429054 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-5UTR | ENST00000369739 | ENST00000259939 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-3UTR | ENST00000369739 | ENST00000486622 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-intron | ENST00000484282 | ENST00000429054 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-5UTR | ENST00000484282 | ENST00000259939 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
| intron-3UTR | ENST00000484282 | ENST00000486622 | DOPEY1 | chr6 | 83777498 | + | RNF144B | chr6 | 18399730 | + |
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FusionProtFeatures for DOPEY1_RNF144B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOPEY1 | RNF144B |