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Fusion gene ID: 10401 |
FusionGeneSummary for DOCK4_NRCAM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK4_NRCAM | Fusion gene ID: 10401 | Hgene | Tgene | Gene symbol | DOCK4 | NRCAM | Gene ID | 9732 | 4897 |
| Gene name | dedicator of cytokinesis 4 | neuronal cell adhesion molecule | |
| Synonyms | - | - | |
| Cytomap | 7q31.1 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 4 | neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo | |
| Modification date | 20180525 | 20180519 | |
| UniProtAcc | Q8N1I0 | Q92823 | |
| Ensembl transtripts involved in fusion gene | ENST00000428084, ENST00000494651, ENST00000437633, ENST00000476846, | ENST00000379028, ENST00000413765, ENST00000351718, ENST00000379024, ENST00000379022, ENST00000425651, ENST00000522550, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 3 X 3 X 3=27 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/60*10)=0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK4 [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NRCAM | GO:0045162 | clustering of voltage-gated sodium channels | 14602817 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-5P-A9JZ-01A | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000428084 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000428084 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000428084 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000428084 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-5UTR | ENST00000494651 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-intron | ENST00000494651 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| intron-intron | ENST00000494651 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-5UTR | ENST00000437633 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000437633 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5CDS-intron | ENST00000437633 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379028 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000413765 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000351718 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379024 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-5UTR | ENST00000476846 | ENST00000379022 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-intron | ENST00000476846 | ENST00000425651 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
| 5UTR-intron | ENST00000476846 | ENST00000522550 | DOCK4 | chr7 | 111846157 | - | NRCAM | chr7 | 107953175 | - |
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FusionProtFeatures for DOCK4_NRCAM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK4 | NRCAM |