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Fusion gene ID: 10386 |
FusionGeneSummary for DOCK1_PPAPDC1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK1_PPAPDC1A | Fusion gene ID: 10386 | Hgene | Tgene | Gene symbol | DOCK1 | PPAPDC1A | Gene ID | 1793 | 196051 |
| Gene name | dedicator of cytokinesis 1 | phospholipid phosphatase 4 | |
| Synonyms | DOCK180|ced5 | DPPL2|PPAPDC1|PPAPDC1A | |
| Cytomap | 10q26.2 | 10q26.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | phospholipid phosphatase 4diacylglycerol pyrophosphate like 2diacylglycerol pyrophosphate phosphatase-like 2phosphatidate phosphatase PPAPDC1Aphosphatidic acid phosphatase type 2 domain containing 1Aphosphatidic acid phosphatase type 2 domain-contain | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q14185 | ||
| Ensembl transtripts involved in fusion gene | ENST00000280333, ENST00000484400, | ENST00000398250, ENST00000439221, ENST00000398248, ENST00000541332, ENST00000369073, ENST00000496437, | |
| Fusion gene scores | * DoF score | 12 X 12 X 8=1152 | 6 X 3 X 6=108 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOCK1 [Title/Abstract] AND PPAPDC1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPAPDC1A | GO:0046839 | phospholipid dephosphorylation | 17590538 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A04U-01A | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000280333 | ENST00000398250 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000439221 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000398248 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000541332 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| In-frame | ENST00000280333 | ENST00000369073 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| 5CDS-intron | ENST00000280333 | ENST00000496437 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000398250 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000439221 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000398248 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000541332 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-3CDS | ENST00000484400 | ENST00000369073 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
| intron-intron | ENST00000484400 | ENST00000496437 | DOCK1 | chr10 | 128796513 | + | PPAPDC1A | chr10 | 122263330 | + |
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FusionProtFeatures for DOCK1_PPAPDC1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK1 | PPAPDC1A |