|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10380 |
FusionGeneSummary for DOCK1_DOCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK1_DOCK1 | Fusion gene ID: 10380 | Hgene | Tgene | Gene symbol | DOCK1 | DOCK1 | Gene ID | 1793 | 1793 |
| Gene name | dedicator of cytokinesis 1 | dedicator of cytokinesis 1 | |
| Synonyms | DOCK180|ced5 | DOCK180|ced5 | |
| Cytomap | 10q26.2 | 10q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q14185 | Q14185 | |
| Ensembl transtripts involved in fusion gene | ENST00000280333, ENST00000484400, | ENST00000280333, ENST00000484400, | |
| Fusion gene scores | * DoF score | 12 X 12 X 8=1152 | 8 X 7 X 5=280 |
| # samples | 13 | 9 | |
| ** MAII score | log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOCK1 [Title/Abstract] AND DOCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE930060 | DOCK1 | chr10 | 128904565 | + | DOCK1 | chr10 | 128859985 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000280333 | ENST00000280333 | DOCK1 | chr10 | 128904565 | + | DOCK1 | chr10 | 128859985 | - |
| 5CDS-intron | ENST00000280333 | ENST00000484400 | DOCK1 | chr10 | 128904565 | + | DOCK1 | chr10 | 128859985 | - |
| intron-3CDS | ENST00000484400 | ENST00000280333 | DOCK1 | chr10 | 128904565 | + | DOCK1 | chr10 | 128859985 | - |
| intron-intron | ENST00000484400 | ENST00000484400 | DOCK1 | chr10 | 128904565 | + | DOCK1 | chr10 | 128859985 | - |
Top |
FusionProtFeatures for DOCK1_DOCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK1 | DOCK1 |