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Fusion gene ID: 10376 |
FusionGeneSummary for DOCK11_KMT2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK11_KMT2A | Fusion gene ID: 10376 | Hgene | Tgene | Gene symbol | DOCK11 | KMT2A | Gene ID | 139818 | 4297 |
| Gene name | dedicator of cytokinesis 11 | lysine methyltransferase 2A | |
| Synonyms | ACG|ZIZ2|bB128O4.1 | ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS | |
| Cytomap | Xq24 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 11Activated Cdc42-associated guanine nucleotide exchange factor, ACGbB128O4.1.1 (novel protein)zizimin-2zizimin2 | histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5JSL3 | Q03164 | |
| Ensembl transtripts involved in fusion gene | ENST00000276204, ENST00000276202, | ENST00000534358, ENST00000389506, ENST00000354520, ENST00000420751, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 15 X 40 X 1=600 |
| # samples | 3 | 58 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(58/600*10)=-0.0489096004809464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOCK11 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KMT2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20861184 |
| Tgene | KMT2A | GO:0051568 | histone H3-K4 methylation | 19556245 |
| Tgene | KMT2A | GO:0065003 | protein-containing complex assembly | 15199122 |
| Tgene | KMT2A | GO:0080182 | histone H3-K4 trimethylation | 20861184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AY246172 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000276204 | ENST00000534358 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276204 | ENST00000389506 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276204 | ENST00000354520 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276204 | ENST00000420751 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276202 | ENST00000534358 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276202 | ENST00000389506 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276202 | ENST00000354520 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
| intron-intron | ENST00000276202 | ENST00000420751 | DOCK11 | chrX | 117683446 | - | KMT2A | chr11 | 118358291 | + |
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FusionProtFeatures for DOCK11_KMT2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK11 | KMT2A |