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Fusion gene ID: 10370 |
FusionGeneSummary for DOCK10_RNU5F-1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK10_RNU5F-1 | Fusion gene ID: 10370 | Hgene | Tgene | Gene symbol | DOCK10 | RNU5F-1 | Gene ID | 55619 | 26828 |
| Gene name | dedicator of cytokinesis 10 | RNA, U5F small nuclear 1 | |
| Synonyms | DRIP2|Nbla10300|ZIZ3 | RNU5F|U5F | |
| Cytomap | 2q36.2 | 1p34.1 | |
| Type of gene | protein-coding | snRNA | |
| Description | dedicator of cytokinesis protein 10dopamine receptor interacting protein 2zizimin3 | - | |
| Modification date | 20180526 | 20180519 | |
| UniProtAcc | Q96BY6 | ||
| Ensembl transtripts involved in fusion gene | ENST00000409592, ENST00000258390, ENST00000474102, | ENST00000362507, | |
| Fusion gene scores | * DoF score | 7 X 6 X 2=84 | 5 X 6 X 1=30 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK10 [Title/Abstract] AND RNU5F-1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DOCK10 | GO:0030334 | regulation of cell migration | 18835169 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF326144 | DOCK10 | chr2 | 225758446 | + | RNU5F-1 | chr1 | 220287683 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000409592 | ENST00000362507 | DOCK10 | chr2 | 225758446 | + | RNU5F-1 | chr1 | 220287683 | - |
| intron-intron | ENST00000258390 | ENST00000362507 | DOCK10 | chr2 | 225758446 | + | RNU5F-1 | chr1 | 220287683 | - |
| intron-intron | ENST00000474102 | ENST00000362507 | DOCK10 | chr2 | 225758446 | + | RNU5F-1 | chr1 | 220287683 | - |
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FusionProtFeatures for DOCK10_RNU5F-1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK10 | RNU5F-1 |