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Fusion gene ID: 10344

FusionGeneSummary for DNMT1_EMR1

Fusion gene summary

Fusion gene information	Fusion gene name: DNMT1_EMR1
	Fusion gene ID: 10344
		Hgene	Tgene
	Gene symbol	DNMT1	EMR1
	Gene ID	1786	2015
	Gene name	DNA methyltransferase 1	adhesion G protein-coupled receptor E1
	Synonyms	ADCADN\|AIM\|CXXC9\|DNMT\|HSN1E\|MCMT\|m.HsaI	EMR1\|TM7LN3
	Cytomap	19p13.2	19p13.3-p13.2
	Type of gene	protein-coding	protein-coding
	Description	DNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaI	adhesion G protein-coupled receptor E1EGF-like module receptor 1EGF-like module-containing mucin-like hormone receptor-like 1EMR1 hormone receptoregf-like module containing, mucin-like, hormone receptor-like 1egf-like module containing, mucin-like, h
	Modification date	20180527	20180523
	UniProtAcc	P26358
	Ensembl transtripts involved in fusion gene	ENST00000340748, ENST00000540357, ENST00000359526, ENST00000589538,	ENST00000250572, ENST00000381407, ENST00000312053, ENST00000450315, ENST00000381404, ENST00000601198,
Fusion gene scores	* DoF score	10 X 9 X 9=810	2 X 2 X 2=8
	# samples	12	2
	** MAII score	log2(12/810*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: DNMT1 [Title/Abstract] AND EMR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DNMT1	GO:0010216	maintenance of DNA methylation	18754681\|21745816

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-FJ-A3ZE-01A	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000340748	ENST00000250572	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000340748	ENST00000381407	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000340748	ENST00000312053	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000340748	ENST00000450315	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000340748	ENST00000381404	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
5CDS-intron	ENST00000340748	ENST00000601198	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000540357	ENST00000250572	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000540357	ENST00000381407	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000540357	ENST00000312053	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000540357	ENST00000450315	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000540357	ENST00000381404	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
5CDS-intron	ENST00000540357	ENST00000601198	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000359526	ENST00000250572	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000359526	ENST00000381407	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000359526	ENST00000312053	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000359526	ENST00000450315	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
In-frame	ENST00000359526	ENST00000381404	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
5CDS-intron	ENST00000359526	ENST00000601198	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-3CDS	ENST00000589538	ENST00000250572	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-3CDS	ENST00000589538	ENST00000381407	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-3CDS	ENST00000589538	ENST00000312053	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-3CDS	ENST00000589538	ENST00000450315	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-3CDS	ENST00000589538	ENST00000381404	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+
intron-intron	ENST00000589538	ENST00000601198	DNMT1	chr19	10266529	-	EMR1	chr19	6890492	+

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FusionProtFeatures for DNMT1_EMR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DNMT1 P26358	EMR1

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Fusion gene ID: 10344

FusionGeneSummary for DNMT1_EMR1

FusionProtFeatures for DNMT1_EMR1