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Fusion gene ID: 10340

FusionGeneSummary for DNMBP_PER1

Fusion gene summary

Fusion gene information	Fusion gene name: DNMBP_PER1
	Fusion gene ID: 10340
		Hgene	Tgene
	Gene symbol	DNMBP	PER1
	Gene ID	23268	5187
	Gene name	dynamin binding protein	period circadian regulator 1
	Synonyms	ARHGEF36\|TUBA	PER\|RIGUI\|hPER
	Cytomap	10q24.2	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	dynamin-binding proteinscaffold protein TUBA	period circadian protein homolog 1Period, drosophila, homolog ofcircadian clock protein PERIOD 1circadian pacemaker protein RIGUIhPER1period circadian clock 1period homolog 1
	Modification date	20180523	20180523
	UniProtAcc	Q6XZF7	O15534
	Ensembl transtripts involved in fusion gene	ENST00000342239, ENST00000324109, ENST00000543621, ENST00000540316, ENST00000472036,	ENST00000317276, ENST00000581082, ENST00000578089, ENST00000354903,
Fusion gene scores	* DoF score	6 X 5 X 4=120	3 X 3 X 2=18
	# samples	6	3
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DNMBP [Title/Abstract] AND PER1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PER1	GO:0032922	circadian regulation of gene expression	18411297\|24005054
Tgene	PER1	GO:0043966	histone H3 acetylation	14645221
Tgene	PER1	GO:0043967	histone H4 acetylation	14645221

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF849664	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000342239	ENST00000317276	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000342239	ENST00000581082	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000342239	ENST00000578089	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000342239	ENST00000354903	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000324109	ENST00000317276	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000324109	ENST00000581082	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000324109	ENST00000578089	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000324109	ENST00000354903	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000543621	ENST00000317276	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000543621	ENST00000581082	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000543621	ENST00000578089	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000543621	ENST00000354903	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000540316	ENST00000317276	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000540316	ENST00000581082	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000540316	ENST00000578089	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000540316	ENST00000354903	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000472036	ENST00000317276	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000472036	ENST00000581082	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000472036	ENST00000578089	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+
intron-intron	ENST00000472036	ENST00000354903	DNMBP	chr10	101635993	+	PER1	chr17	8050160	+

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FusionProtFeatures for DNMBP_PER1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DNMBP Q6XZF7	PER1 O15534

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Fusion gene ID: 10340

FusionGeneSummary for DNMBP_PER1

FusionProtFeatures for DNMBP_PER1