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Fusion gene ID: 10314 |
FusionGeneSummary for DNM2_GDF15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNM2_GDF15 | Fusion gene ID: 10314 | Hgene | Tgene | Gene symbol | DNM2 | GDF15 | Gene ID | 1785 | 9518 |
| Gene name | dynamin 2 | growth differentiation factor 15 | |
| Synonyms | CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5 | GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB | |
| Cytomap | 19p13.2 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dynamin-2dynamin II | growth/differentiation factor 15NRG-1NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1NSAID-activated gene 1 proteinNSAID-regulated gene 1 proteinPTGF-betamacrophage inhibitory cytokine 1non-steroidal anti-inflammatory drug-activated | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P50570 | Q99988 | |
| Ensembl transtripts involved in fusion gene | ENST00000585892, ENST00000314646, ENST00000359692, ENST00000389253, ENST00000355667, ENST00000408974, ENST00000591819, | ENST00000604609, ENST00000252809, | |
| Fusion gene scores | * DoF score | 27 X 13 X 12=4212 | 3 X 3 X 3=27 |
| # samples | 31 | 3 | |
| ** MAII score | log2(31/4212*10)=-3.76416531575148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DNM2 [Title/Abstract] AND GDF15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNM2 | GO:1903526 | negative regulation of membrane tubulation | 18388313 |
| Tgene | GDF15 | GO:0000187 | activation of MAPK activity | 28953886 |
| Tgene | GDF15 | GO:0002023 | reduction of food intake in response to dietary excess | 28846097|28846098|28846099|28953886|29046435 |
| Tgene | GDF15 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Tgene | GDF15 | GO:0051897 | positive regulation of protein kinase B signaling | 28846097 |
| Tgene | GDF15 | GO:0060395 | SMAD protein signal transduction | 25893289 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A2QS-01A | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000585892 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000585892 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000314646 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000314646 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000359692 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000359692 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000389253 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000389253 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000355667 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000355667 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000408974 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000408974 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| intron-3UTR | ENST00000591819 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| intron-intron | ENST00000591819 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
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FusionProtFeatures for DNM2_GDF15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNM2 | GDF15 |