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Fusion gene ID: 10258 |
FusionGeneSummary for DNAJC3_CBFA2T2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJC3_CBFA2T2 | Fusion gene ID: 10258 | Hgene | Tgene | Gene symbol | DNAJC3 | CBFA2T2 | Gene ID | 5611 | 9139 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C3 | CBFA2/RUNX1 translocation partner 2 | |
| Synonyms | ACPHD|ERdj6|HP58|P58|P58IPK|PRKRI | EHT|MTGR1|ZMYND3|p85 | |
| Cytomap | 13q32.1 | 20q11.21-q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhib | protein CBFA2T2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-related protein 1myeloid translocation- | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13217 | O43439 | |
| Ensembl transtripts involved in fusion gene | ENST00000602402, ENST00000376795, | ENST00000342704, ENST00000375279, ENST00000344201, ENST00000397798, ENST00000346541, ENST00000397800, ENST00000492345, ENST00000359606, ENST00000491618, ENST00000543126, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 11 X 10 X 8=880 |
| # samples | 9 | 15 | |
| ** MAII score | log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/880*10)=-2.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJC3 [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CBFA2T2 | GO:0010976 | positive regulation of neuron projection development | 19026687 |
| Tgene | CBFA2T2 | GO:0045892 | negative regulation of transcription, DNA-templated | 23251453 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG992563 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000602402 | ENST00000342704 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000375279 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000344201 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000397798 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000346541 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000397800 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000492345 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000359606 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000491618 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| 3UTR-intron | ENST00000602402 | ENST00000543126 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000342704 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000375279 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000344201 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000397798 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000346541 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000397800 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000492345 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000359606 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000491618 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
| intron-intron | ENST00000376795 | ENST00000543126 | DNAJC3 | chr13 | 96444658 | - | CBFA2T2 | chr20 | 32110101 | + |
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FusionProtFeatures for DNAJC3_CBFA2T2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJC3 | CBFA2T2 |