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Fusion gene ID: 10246 |
FusionGeneSummary for DNAJC21_SGCZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJC21_SGCZ | Fusion gene ID: 10246 | Hgene | Tgene | Gene symbol | DNAJC21 | SGCZ | Gene ID | 134218 | 137868 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C21 | sarcoglycan zeta | |
| Synonyms | BMFS3|DNAJA5|GS3|JJJ1 | ZSG1 | |
| Cytomap | 5p13.2 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily C member 21DnaJ (Hsp40) homolog, subfamily C, member 21DnaJ homology subfamily A member 5JJJ1 DnaJ domain protein homologdnaJ homolog subfamily A member 5 | zeta-sarcoglycanzeta-SG | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q5F1R6 | Q96LD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000342382, ENST00000303525, ENST00000382021, ENST00000512136, | ENST00000382080, ENST00000421524, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 4 X 5=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJC21 [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5KX-01A | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000342382 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000342382 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| Frame-shift | ENST00000303525 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000303525 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| Frame-shift | ENST00000382021 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000382021 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| intron-3CDS | ENST00000512136 | ENST00000382080 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
| intron-intron | ENST00000512136 | ENST00000421524 | DNAJC21 | chr5 | 34930021 | + | SGCZ | chr8 | 14181713 | - |
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FusionProtFeatures for DNAJC21_SGCZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJC21 | SGCZ |