|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10218 |
FusionGeneSummary for DNAJB6_AGT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB6_AGT | Fusion gene ID: 10218 | Hgene | Tgene | Gene symbol | DNAJB6 | AGT | Gene ID | 10049 | 189 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B6 | alanine--glyoxylate and serine--pyruvate aminotransferase | |
| Synonyms | DJ4|DnaJ|HHDJ1|HSJ-2|HSJ2|LGMD1D|LGMD1E|MRJ|MSJ-1 | AGT|AGT1|AGXT1|PH1|SPAT|SPT|TLH6 | |
| Cytomap | 7q36.3 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily B member 6DnaJ (Hsp40) homolog, subfamily B, member 6DnaJ-like 2 proteinheat shock protein J2 | serine--pyruvate aminotransferaseL-alanine: glyoxylate aminotransferase 1alanine-glyoxylate aminotransferasehepatic peroxisomal alanine:glyoxylate aminotransferase | |
| Modification date | 20180529 | 20180523 | |
| UniProtAcc | O75190 | P01019 | |
| Ensembl transtripts involved in fusion gene | ENST00000429029, ENST00000262177, ENST00000452797, ENST00000443280, ENST00000494267, | ENST00000366667, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DNAJB6 [Title/Abstract] AND AGT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJB6 | GO:0006457 | protein folding | 11896048 |
| Hgene | DNAJB6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11896048 |
| Hgene | DNAJB6 | GO:0045109 | intermediate filament organization | 10954706 |
| Hgene | DNAJB6 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Tgene | AGT | GO:0009436 | glyoxylate catabolic process | 22198249 |
| Tgene | AGT | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 22198249 |
| Tgene | AGT | GO:0019448 | L-cysteine catabolic process | 18492492 |
| Tgene | AGT | GO:0042853 | L-alanine catabolic process | 17696873|18492492|22198249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-98-A53H-01A | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000429029 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| In-frame | ENST00000262177 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| In-frame | ENST00000452797 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| intron-3CDS | ENST00000443280 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
| intron-3CDS | ENST00000494267 | ENST00000366667 | DNAJB6 | chr7 | 157178305 | + | AGT | chr1 | 230841946 | - |
Top |
FusionProtFeatures for DNAJB6_AGT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB6 | AGT |