	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 10159

FusionGeneSummary for DMTN_PKN2

Fusion gene summary

Fusion gene information	Fusion gene name: DMTN_PKN2
	Fusion gene ID: 10159
		Hgene	Tgene
	Gene symbol	DMTN	PKN2
	Gene ID	2039	5586
	Gene name	dematin actin binding protein	protein kinase N2
	Synonyms	DMT\|EPB49	PAK2\|PRK2\|PRKCL2\|PRO2042\|Pak-2\|STK7
	Cytomap	8p21.3	1p22.2
	Type of gene	protein-coding	protein-coding
	Description	dematinerythrocyte membrane protein band 4.9 (dematin)	serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2
	Modification date	20180523	20180523
	UniProtAcc	Q08495	Q16513
	Ensembl transtripts involved in fusion gene	ENST00000381470, ENST00000432128, ENST00000443491, ENST00000517600, ENST00000523782, ENST00000265800, ENST00000415253, ENST00000358242, ENST00000523266, ENST00000519907,	ENST00000316005, ENST00000370521, ENST00000370505, ENST00000370513, ENST00000544045, ENST00000495119,
Fusion gene scores	* DoF score	4 X 4 X 4=64	4 X 2 X 3=24
	# samples	6	3
	** MAII score	log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DMTN [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DMTN	GO:0032956	regulation of actin cytoskeleton organization	22927433
Hgene	DMTN	GO:0065003	protein-containing complex assembly	18347014
Hgene	DMTN	GO:0071320	cellular response to cAMP	22927433
Tgene	PKN2	GO:0006468	protein phosphorylation	17332740
Tgene	PKN2	GO:0010631	epithelial cell migration	21754995

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BP417512	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000381470	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000381470	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000381470	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000381470	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000381470	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000381470	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000432128	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000432128	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000432128	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000432128	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000432128	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000432128	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000443491	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000443491	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000443491	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000443491	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000443491	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000443491	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000517600	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000517600	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000517600	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000517600	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000517600	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000517600	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523782	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000523782	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523782	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523782	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523782	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523782	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000265800	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000265800	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000265800	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000265800	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000265800	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000265800	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000415253	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000415253	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000415253	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000415253	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000415253	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000415253	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000358242	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000358242	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000358242	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000358242	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000358242	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000358242	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523266	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000523266	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523266	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523266	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523266	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000523266	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000519907	ENST00000316005	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-3UTR	ENST00000519907	ENST00000370521	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000519907	ENST00000370505	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000519907	ENST00000370513	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000519907	ENST00000544045	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+
intron-intron	ENST00000519907	ENST00000495119	DMTN	chr8	21927698	-	PKN2	chr1	89299434	+

Top

FusionProtFeatures for DMTN_PKN2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DMTN Q08495	PKN2 Q16513

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 10159

FusionGeneSummary for DMTN_PKN2

FusionProtFeatures for DMTN_PKN2