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Fusion gene ID: 10080 |
FusionGeneSummary for DLG1_LPP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DLG1_LPP | Fusion gene ID: 10080 | Hgene | Tgene | Gene symbol | DLG1 | LPP | Gene ID | 1739 | 4026 |
| Gene name | discs large MAGUK scaffold protein 1 | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | DLGH1|SAP-97|SAP97|dJ1061C18.1.1|hdlg | - | |
| Cytomap | 3q29 | 3q27.3-q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disks large homolog 1discs large homolog 1, scribble cell polarity complex componentdiscs, large homolog 1 transcript variant 6-v1discs, large homolog 1 transcript variant 6-v2presynaptic protein SAP97synapse-associated protein 97 | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q12959 | Q93052 | |
| Ensembl transtripts involved in fusion gene | ENST00000357674, ENST00000314062, ENST00000346964, ENST00000419354, ENST00000452595, ENST00000422288, ENST00000448528, ENST00000443183, ENST00000450955, ENST00000392382, ENST00000485409, | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | |
| Fusion gene scores | * DoF score | 20 X 10 X 13=2600 | 12 X 17 X 5=1020 |
| # samples | 23 | 20 | |
| ** MAII score | log2(23/2600*10)=-3.49880585697144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1020*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DLG1 [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DLG1 | GO:0001935 | endothelial cell proliferation | 14699157 |
| Hgene | DLG1 | GO:0007015 | actin filament organization | 14699157 |
| Hgene | DLG1 | GO:0030866 | cortical actin cytoskeleton organization | 14699157 |
| Hgene | DLG1 | GO:0042391 | regulation of membrane potential | 12970345 |
| Hgene | DLG1 | GO:0043268 | positive regulation of potassium ion transport | 12970345 |
| Hgene | DLG1 | GO:0070830 | bicellular tight junction assembly | 17332497 |
| Hgene | DLG1 | GO:0098609 | cell-cell adhesion | 14699157 |
| Hgene | DLG1 | GO:1903078 | positive regulation of protein localization to plasma membrane | 12970345 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF155584 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000357674 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000357674 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000357674 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000357674 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000314062 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000314062 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000314062 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000314062 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000346964 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000346964 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000346964 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000346964 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000419354 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000419354 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000419354 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000419354 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000452595 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000452595 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000452595 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000452595 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000422288 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000422288 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000422288 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000422288 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000448528 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000448528 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000448528 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000448528 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000443183 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000443183 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000443183 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000443183 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000450955 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000450955 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000450955 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000450955 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000392382 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000392382 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000392382 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000392382 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000485409 | ENST00000448637 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000485409 | ENST00000312675 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000485409 | ENST00000543006 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
| intron-intron | ENST00000485409 | ENST00000471917 | DLG1 | chr3 | 196846404 | + | LPP | chr3 | 188327632 | - |
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FusionProtFeatures for DLG1_LPP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DLG1 | LPP |