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Fusion gene ID: 10056 |
FusionGeneSummary for DLD_SCEL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DLD_SCEL | Fusion gene ID: 10056 | Hgene | Tgene | Gene symbol | DLD | SCEL | Gene ID | 60343 | 8796 |
| Gene name | family with sequence similarity 3 member A | sciellin | |
| Synonyms | 2.19|DLD|DXS560S|XAP-7 | - | |
| Cytomap | Xq28 | 13q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM3Acytokine-like protein 2-19 | sciellin | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P09622 | O95171 | |
| Ensembl transtripts involved in fusion gene | ENST00000205402, ENST00000537148, ENST00000440410, ENST00000437604, ENST00000494441, | ENST00000535157, ENST00000377246, ENST00000349847, ENST00000469982, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DLD [Title/Abstract] AND SCEL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DLD | GO:0019732 | antifungal humoral response | 18212107 |
| Hgene | DLD | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 18212107 |
| Hgene | DLD | GO:1905035 | negative regulation of antifungal innate immune response | 18212107 |
| Tgene | SCEL | GO:0030216 | keratinocyte differentiation | 14632196 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VN-A88L-01A | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000205402 | ENST00000535157 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000205402 | ENST00000377246 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000205402 | ENST00000349847 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5CDS-3UTR | ENST00000205402 | ENST00000469982 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5UTR-3CDS | ENST00000537148 | ENST00000535157 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5UTR-3CDS | ENST00000537148 | ENST00000377246 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5UTR-3CDS | ENST00000537148 | ENST00000349847 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5UTR-3UTR | ENST00000537148 | ENST00000469982 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000440410 | ENST00000535157 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000440410 | ENST00000377246 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000440410 | ENST00000349847 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5CDS-3UTR | ENST00000440410 | ENST00000469982 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000437604 | ENST00000535157 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000437604 | ENST00000377246 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| Frame-shift | ENST00000437604 | ENST00000349847 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| 5CDS-3UTR | ENST00000437604 | ENST00000469982 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| intron-3CDS | ENST00000494441 | ENST00000535157 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| intron-3CDS | ENST00000494441 | ENST00000377246 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| intron-3CDS | ENST00000494441 | ENST00000349847 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
| intron-3UTR | ENST00000494441 | ENST00000469982 | DLD | chr7 | 107531734 | + | SCEL | chr13 | 78171680 | + |
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FusionProtFeatures for DLD_SCEL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DLD | SCEL |