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Fusion gene ID: 10044 |
FusionGeneSummary for DIXDC1_DIXDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIXDC1_DIXDC1 | Fusion gene ID: 10044 | Hgene | Tgene | Gene symbol | DIXDC1 | DIXDC1 | Gene ID | 85458 | 85458 |
| Gene name | DIX domain containing 1 | DIX domain containing 1 | |
| Synonyms | CCD1 | CCD1 | |
| Cytomap | 11q23.1 | 11q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dixincoiled-coil protein DIX1 | dixincoiled-coil protein DIX1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q155Q3 | Q155Q3 | |
| Ensembl transtripts involved in fusion gene | ENST00000529225, ENST00000440460, ENST00000389821, ENST00000531396, ENST00000315253, | ENST00000529225, ENST00000440460, ENST00000389821, ENST00000531396, ENST00000315253, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 2 X 2 X 1=4 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: DIXDC1 [Title/Abstract] AND DIXDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DIXDC1 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21189423 |
| Tgene | DIXDC1 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21189423 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA633772 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000529225 | ENST00000529225 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000529225 | ENST00000440460 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000529225 | ENST00000389821 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-intron | ENST00000529225 | ENST00000531396 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000529225 | ENST00000315253 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000440460 | ENST00000529225 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000440460 | ENST00000440460 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000440460 | ENST00000389821 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000440460 | ENST00000531396 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000440460 | ENST00000315253 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000389821 | ENST00000529225 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000389821 | ENST00000440460 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000389821 | ENST00000389821 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000389821 | ENST00000531396 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000389821 | ENST00000315253 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-intron | ENST00000531396 | ENST00000529225 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000531396 | ENST00000440460 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000531396 | ENST00000389821 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-intron | ENST00000531396 | ENST00000531396 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| intron-3UTR | ENST00000531396 | ENST00000315253 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000315253 | ENST00000529225 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000315253 | ENST00000440460 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000315253 | ENST00000389821 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-intron | ENST00000315253 | ENST00000531396 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
| 3UTR-3UTR | ENST00000315253 | ENST00000315253 | DIXDC1 | chr11 | 111893083 | - | DIXDC1 | chr11 | 111892908 | + |
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FusionProtFeatures for DIXDC1_DIXDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIXDC1 | DIXDC1 |