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Fusion gene ID: 10041 |
FusionGeneSummary for DISP2_TMED10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DISP2_TMED10 | Fusion gene ID: 10041 | Hgene | Tgene | Gene symbol | DISP2 | TMED10 | Gene ID | 85455 | 10972 |
| Gene name | dispatched RND transporter family member 2 | transmembrane p24 trafficking protein 10 | |
| Synonyms | C15orf36|DISPB|HsT16908|LINC00594 | P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1 | |
| Cytomap | 15q15.1 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein dispatched homolog 2dispatched Blong intergenic non-protein coding RNA 594 | transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21 | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | A7MBM2 | P49755 | |
| Ensembl transtripts involved in fusion gene | ENST00000267889, | ENST00000303575, ENST00000557670, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 4 X 4=96 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DISP2 [Title/Abstract] AND TMED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TMED10 | GO:0006886 | intracellular protein transport | 20427317 |
| Tgene | TMED10 | GO:0035964 | COPI-coated vesicle budding | 10052452 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK026919 | DISP2 | chr15 | 40663520 | + | TMED10 | chr14 | 75598857 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000267889 | ENST00000303575 | DISP2 | chr15 | 40663520 | + | TMED10 | chr14 | 75598857 | - |
| intron-intron | ENST00000267889 | ENST00000557670 | DISP2 | chr15 | 40663520 | + | TMED10 | chr14 | 75598857 | - |
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FusionProtFeatures for DISP2_TMED10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DISP2 | TMED10 |