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Fusion gene ID: 10036 |
FusionGeneSummary for DIS3_KLF12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIS3_KLF12 | Fusion gene ID: 10036 | Hgene | Tgene | Gene symbol | DIS3 | KLF12 | Gene ID | 22894 | 11278 |
| Gene name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | Kruppel like factor 12 | |
| Synonyms | 2810028N01Rik|EXOSC11|KIAA1008|RRP44|dis3p | AP-2rep|AP2REP|HSPC122 | |
| Cytomap | 13q21.33 | 13q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exosome complex exonuclease RRP44DIS3 exosome endoribonuclease and 3'-5' exoribonucleaseDIS3 mitotic control homologexosome component 11mitotic control protein dis3 homologribosomal RNA-processing protein 44 | Krueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2L1 | Q9Y4X4 | |
| Ensembl transtripts involved in fusion gene | ENST00000377767, ENST00000377780, ENST00000545453, ENST00000475871, | ENST00000377669, ENST00000377666, ENST00000472022, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 10 X 4=360 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DIS3 [Title/Abstract] AND KLF12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KLF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16615998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A922-01A | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377767 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377767 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000377767 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000377780 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000545453 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-5UTR | ENST00000475871 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
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FusionProtFeatures for DIS3_KLF12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIS3 | KLF12 |